Menu
×
West Ashley Library
9 a.m. - 7 p.m.
Phone: (843) 766-6635
Folly Beach Library
9 a.m. - 5:30 p.m.
Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
Closed for renovations
Phone: (843) 883-3914
Wando Mount Pleasant Library
9 a.m. - 8 p.m.
Phone: (843) 805-6888
Village Library
9 a.m. - 6 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. - 8 p.m.
Phone: (843) 889-3300
Otranto Road Library
9 a.m. - 8 p.m.
Phone: (843) 572-4094
Mt. Pleasant Library
9 a.m. - 8 p.m.
Phone: (843) 849-6161
McClellanville Library
9 a.m. - 6 p.m.
Phone: (843) 887-3699
Keith Summey North Charleston Library
9 a.m. - 8 p.m.
Phone: (843) 744-2489
John's Island Library
9 a.m. - 8 p.m.
Phone: (843) 559-1945
Hurd/St. Andrews Library
9 a.m. - 8 p.m.
Phone: (843) 766-2546
Miss Jane's Building (Edisto Library Temporary Location)
9 a.m. - 4 p.m.
Phone: (843) 869-2355
Dorchester Road Library
9 a.m. - 8 p.m.
Phone: (843) 552-6466
John L. Dart Library
9 a.m. - 7 p.m.
Phone: (843) 722-7550
Baxter-Patrick James Island
9 a.m. - 8 p.m.
Phone: (843) 795-6679
Main Library
9 a.m. - 8 p.m.
Phone: (843) 805-6930
Bees Ferry West Ashley Library
9 a.m. - 8 p.m.
Phone: (843) 805-6892
Mobile Library
9 a.m. - 5 p.m.
Phone: (843) 805-6909
Today's Hours
West Ashley Library
9 a.m. - 7 p.m.
Phone: (843) 766-6635
Folly Beach Library
9 a.m. - 5:30 p.m.
Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
Closed for renovations
Phone: (843) 883-3914
Wando Mount Pleasant Library
9 a.m. - 8 p.m.
Phone: (843) 805-6888
Village Library
9 a.m. - 6 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. - 8 p.m.
Phone: (843) 889-3300
Otranto Road Library
9 a.m. - 8 p.m.
Phone: (843) 572-4094
Mt. Pleasant Library
9 a.m. - 8 p.m.
Phone: (843) 849-6161
McClellanville Library
9 a.m. - 6 p.m.
Phone: (843) 887-3699
Keith Summey North Charleston Library
9 a.m. - 8 p.m.
Phone: (843) 744-2489
John's Island Library
9 a.m. - 8 p.m.
Phone: (843) 559-1945
Hurd/St. Andrews Library
9 a.m. - 8 p.m.
Phone: (843) 766-2546
Miss Jane's Building (Edisto Library Temporary Location)
9 a.m. - 4 p.m.
Phone: (843) 869-2355
Dorchester Road Library
9 a.m. - 8 p.m.
Phone: (843) 552-6466
John L. Dart Library
9 a.m. - 7 p.m.
Phone: (843) 722-7550
Baxter-Patrick James Island
9 a.m. - 8 p.m.
Phone: (843) 795-6679
Main Library
9 a.m. - 8 p.m.
Phone: (843) 805-6930
Bees Ferry West Ashley Library
9 a.m. - 8 p.m.
Phone: (843) 805-6892
Mobile Library
9 a.m. - 5 p.m.
Phone: (843) 805-6909
Patron Login
menu
Item request has been placed!
×
Item request cannot be made.
×
![loading](/sites/all/modules/hf_eds/images/loading.gif)
Single-cell analysis reveals a subpopulation of adipose progenitor cells that impairs glucose homeostasis.
Item request has been placed!
×
Item request cannot be made.
×
![loading](/sites/all/modules/hf_eds/images/loading.gif)
- Author(s): Wang H;Wang H; Du Y; Du Y; Huang S; Huang S; Sun X; Sun X; Ye Y; Ye Y; Sun H; Sun H; Chu X; Chu X; Shan X; Shan X; Yuan Y; Yuan Y; Shen L; Shen L; Bi Y; Bi Y
- Source:
Nature communications [Nat Commun] 2024 Jun 06; Vol. 15 (1), pp. 4827. Date of Electronic Publication: 2024 Jun 06.- Publication Type:
Journal Article- Language:
English - Source:
- Additional Information
- Source: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
- Publication Information: Original Publication: [London] : Nature Pub. Group
- Subject Terms: Single-Cell Analysis*/methods ; Diabetes Mellitus, Type 2*/metabolism ; Homeostasis* ; Stem Cells*/metabolism ; Glucose*/metabolism ; Obesity*/metabolism ; Obesity*/pathology; Humans ; Animals ; Male ; Mice ; Adipocytes/metabolism ; Intra-Abdominal Fat/metabolism ; Intra-Abdominal Fat/cytology ; Adipose Tissue/metabolism ; Adipose Tissue/cytology ; Mice, Inbred C57BL ; Lipolysis ; Female ; Middle Aged
- Abstract: Adipose progenitor cells (APCs) are heterogeneous stromal cells and help to maintain metabolic homeostasis. However, the influence of obesity on human APC heterogeneity and the role of APC subpopulations on regulating glucose homeostasis remain unknown. Here, we find that APCs in human visceral adipose tissue contain four subsets. The composition and functionality of APCs are altered in patients with type 2 diabetes (T2D). CD9 + CD55 low APCs are the subset which is significantly increased in T2D patients. Transplantation of these cells from T2D patients into adipose tissue causes glycemic disturbance. Mechanistically, CD9 + CD55 low APCs promote T2D development through producing bioactive proteins to form a detrimental niche, leading to upregulation of adipocyte lipolysis. Depletion of pathogenic APCs by inducing intracellular diphtheria toxin A expression or using a hunter-killer peptide improves obesity-related glycemic disturbance. Collectively, our data provide deeper insights in human APC functionality and highlights APCs as a potential therapeutic target to combat T2D. All mice utilized in this study are male.
(© 2024. The Author(s).) - References: Cell. 2015 Feb 12;160(4):745-758. (PMID: 25662011)
Cell. 2022 Feb 3;185(3):419-446. (PMID: 35120662)
Nature. 2021 Sep;597(7876):410-414. (PMID: 34408322)
Cell Metab. 2012 Jan 4;15(1):38-50. (PMID: 22225875)
Cell Syst. 2019 Apr 24;8(4):281-291.e9. (PMID: 30954476)
Elife. 2024 May 22;12:. (PMID: 38775132)
Nat Metab. 2020 Nov;2(11):1332-1349. (PMID: 33139957)
Biochim Biophys Acta. 2010 Mar;1801(3):338-49. (PMID: 20056169)
Sci Immunol. 2019 May 3;4(35):. (PMID: 31053655)
Elife. 2018 Sep 28;7:. (PMID: 30265241)
BMC Genomics. 2018 Jun 19;19(1):477. (PMID: 29914354)
Cell Metab. 2022 Mar 1;34(3):458-472.e6. (PMID: 35021043)
Lancet Diabetes Endocrinol. 2019 Mar;7(3):231-240. (PMID: 30704950)
Nat Metab. 2020 Dec;2(12):1482-1497. (PMID: 33324010)
Diabetes Care. 2017 Jan;40(Suppl 1):S11-S24. (PMID: 27979889)
Science. 2001 Jul 13;293(5528):306-11. (PMID: 11452127)
Cell Metab. 2022 May 3;34(5):783-799.e7. (PMID: 35447091)
Nature. 2001 May 10;411(6834):207-11. (PMID: 11346799)
Nat Metab. 2020 Jan;2(1):97-109. (PMID: 32066997)
Lancet. 2022 Nov 19;400(10365):1803-1820. (PMID: 36332637)
OMICS. 2012 May;16(5):284-7. (PMID: 22455463)
Cell Metab. 2021 Feb 2;33(2):437-453.e5. (PMID: 33378646)
Sci Rep. 2015 May 18;5:10227. (PMID: 25984973)
Cell Metab. 2022 Sep 6;34(9):1264-1279.e8. (PMID: 36070680)
Diabetes. 2009 Mar;58(3):627-36. (PMID: 19056610)
Mol Cell. 2021 Sep 16;81(18):3708-3730. (PMID: 34547235)
Nat Methods. 2017 Oct;14(10):979-982. (PMID: 28825705)
Nat Methods. 2019 Dec;16(12):1289-1296. (PMID: 31740819)
Cell. 2021 Jun 24;184(13):3573-3587.e29. (PMID: 34062119)
Science. 2019 Apr 26;364(6438):. (PMID: 31023895)
Trends Endocrinol Metab. 2014 May;25(5):255-62. (PMID: 24731595)
Circ Res. 2021 Nov 12;129(11):1021-1035. (PMID: 34610755)
Sci Immunol. 2019 May 3;4(35):. (PMID: 31053654)
Nat Med. 2013 Oct;19(10):1338-44. (PMID: 23995282)
Diabetes. 2012 Sep;61(9):2248-54. (PMID: 22554827)
Cell Metab. 2018 Jul 03;28(1):45-54.e3. (PMID: 29861390)
J Hepatol. 2008 Mar;48(3):471-8. (PMID: 18191271)
Nature. 2018 Jul;559(7712):103-108. (PMID: 29925944)
Cell Rep. 2019 Apr 2;27(1):213-225.e5. (PMID: 30943403)
Cell Death Differ. 2015 Feb;22(2):351-63. (PMID: 25342467)
Cell Metab. 2022 Jan 4;34(1):186. (PMID: 34986334)
Diabetes. 2016 Sep;65(9):2502-15. (PMID: 27284105)
Nat Rev Endocrinol. 2019 Sep;15(9):507-524. (PMID: 31296970)
Cell Rep. 2019 Apr 30;27(5):1528-1540.e7. (PMID: 31042478)
Nat Immunol. 2021 May;22(5):639-653. (PMID: 33907320)
Nat Commun. 2019 Jul 22;10(1):3254. (PMID: 31332184)
Nature. 2019 Feb;566(7745):496-502. (PMID: 30787437)
BMC Bioinformatics. 2008 Dec 29;9:559. (PMID: 19114008)
Cell Metab. 2017 Mar 7;25(3):673-685. (PMID: 28215843)
J Clin Endocrinol Metab. 2005 Dec;90(12):6588-95. (PMID: 16189260)
JAMA. 2021 Dec 28;326(24):2498-2506. (PMID: 34962526)
Nat Cell Biol. 2015 Apr;17(4):376-85. (PMID: 25730471)
Nature. 2022 Mar;603(7903):926-933. (PMID: 35296864)
Cell Metab. 2009 Jul;10(1):40-7. (PMID: 19583952)
Nat Protoc. 2020 Apr;15(4):1484-1506. (PMID: 32103204) - Accession Number: IY9XDZ35W2 (Glucose)
- Publication Date: Date Created: 20240606 Date Completed: 20240606 Latest Revision: 20240609
- Publication Date: 20240609
- Accession Number: PMC11156882
- Accession Number: 10.1038/s41467-024-48914-w
- Accession Number: 38844451
- Source:
Contact CCPL
Copyright 2022 Charleston County Public Library Powered By EBSCO Stacks 3.3.0 [350.3] | Staff Login
No Comments.