A marine-derived antioxidant astaxanthin as a potential neuroprotective and neurotherapeutic agent: A review of its efficacy on neurodegenerative conditions.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Author(s): Adıgüzel E;Adıgüzel E; Ülger TG; Ülger TG
  • Source:
    European journal of pharmacology [Eur J Pharmacol] 2024 Aug 15; Vol. 977, pp. 176706. Date of Electronic Publication: 2024 Jun 04.
  • Publication Type:
    Journal Article; Systematic Review; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE
    • Publication Information:
      Publication: 2005- : Amsterdam : Elsevier Science
      Original Publication: Amsterdam, North Holland Pub. Co.
    • Subject Terms:
      Xanthophylls*/pharmacology ; Xanthophylls*/therapeutic use ; Neuroprotective Agents*/pharmacology ; Neuroprotective Agents*/therapeutic use ; Neurodegenerative Diseases*/drug therapy ; Neurodegenerative Diseases*/prevention & control ; Antioxidants*/pharmacology ; Antioxidants*/therapeutic use; Humans ; Animals ; Aquatic Organisms
    • Abstract:
      Astaxanthin is a potent lipid-soluble carotenoid produced by several different freshwater and marine microorganisms, including microalgae, bacteria, fungi, and yeast. The proven therapeutic effects of astaxanthin against different diseases have made this carotenoid popular in the nutraceutical market and among consumers. Recently, astaxanthin is also receiving attention for its effects in the co-adjuvant treatment or prevention of neurological pathologies. In this systematic review, studies evaluating the efficacy of astaxanthin against different neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, cerebrovascular diseases, and spinal cord injury are analyzed. Based on the current literature, astaxanthin shows potential biological activity in both in vitro and in vivo models. In addition, its preventive and therapeutic activities against the above-mentioned diseases have been emphasized in studies with different experimental designs. In contrast, none of the 59 studies reviewed reported any safety concerns or adverse health effects as a result of astaxanthin supplementation. The preventive or therapeutic role of astaxanthin may vary depending on the dosage and route of administration. Although there is a consensus in the literature regarding its effectiveness against the specified diseases, it is important to determine the safe intake levels of synthetic and natural forms and to determine the most effective forms for oral intake.
      Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
      (Copyright © 2024 Elsevier B.V. All rights reserved.)
    • Contributed Indexing:
      Keywords: Alzheimer's disease; Astaxanthin; Cerebral ischemia-reperfusion; Parkinson's disease; Spinal cord injury; Subarachnoid hemorrhage
    • Accession Number:
      0 (Xanthophylls)
      8XPW32PR7I (astaxanthine)
      0 (Neuroprotective Agents)
      0 (Antioxidants)
    • Publication Date:
      Date Created: 20240606 Date Completed: 20240701 Latest Revision: 20240702
    • Publication Date:
      20240703
    • Accession Number:
      10.1016/j.ejphar.2024.176706
    • Accession Number:
      38843946