The correlations between angiopoietin like 8 and cardiometabolic risk factors in Saudi women with type 2 diabetes mellitus: A pilot study.

Publisher: Sage Publications Country of Publication: England NLM ID: 101234011 Publication Model: Print Cited Medium: Internet ISSN: 1752-8984 (Electronic) Linking ISSN: 14791641 NLM ISO Abbreviation: Diab Vasc Dis Res Subsets: MEDLINE

Publication: 2009- : London : Sage Publications
Original Publication: Edgbaston, Birmingham, UK : Sherborne Gibbs, c2005-

Diabetes Mellitus, Type 2*/blood ; Diabetes Mellitus, Type 2*/diagnosis ; Diabetes Mellitus, Type 2*/epidemiology ; Angiopoietin-like Proteins*/blood ; Angiopoietin-Like Protein 8* ; Biomarkers*/blood ; Insulin Resistance* ; Blood Glucose*/metabolism ; Cardiovascular Diseases*/epidemiology ; Cardiovascular Diseases*/diagnosis ; Cardiovascular Diseases*/blood ; Body Mass Index* ; Cardiometabolic Risk Factors*; Humans ; Female ; Middle Aged ; Pilot Projects ; Case-Control Studies ; Saudi Arabia/epidemiology ; Adult ; C-Reactive Protein/analysis ; C-Reactive Protein/metabolism ; Peptide Hormones/blood ; Risk Assessment ; Triglycerides/blood ; Insulin/blood ; Risk Factors

Purpose: This study examines whether Angiopoietin Like 8 (ANGPTL8) is linked to cardiometabolic risk factors (CMRFs) in Saudi women with type 2 diabetes (T2DM).
Methods: Case-control investigation compared 150 women aged 30-60 with T2DM to 140 healthy women of the same age and gender.
Results: ANGPTL8 levels differed significantly between T2DM and non-diabetics. Fasting blood glucose (FBG), insulin resistance (IR), triglycerides (TG), high-sensitivity C-reactive protein (hs-CRP), body mass index (BMI), and atherogenic index (AIP) of plasma all correlated positively with ANGPTL8 concentrations. Insulin levels correlated negatively with ANGPTL8. Multiple linear regression models showed that elevated ANGPTL8 independently predicted higher FBG, hs-CRP, IR, TG, and AIP in T2DM patients.
Conclusion: The study found a significant association between ANGPTL8 levels and IR, hs-CRP, TG, AIP, and BMI in women with T2DM. These components are classified as CMRFs and have the potential to contribute to the development of cardiovascular disease (CVD).
Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Minerva Endocrinol. 2019 Sep;44(3):259-263. (PMID: 29205013)
J Diabetes Res. 2017;2017:8293207. (PMID: 29082263)
Dis Markers. 2016;2016:9391837. (PMID: 27242389)
Diabetologia. 2014 Oct;57(10):2232-4. (PMID: 25099942)
Semergen. 2019 Apr;45(3):147-155. (PMID: 30327259)
Diabetes Res Clin Pract. 2016 Oct;120:229-31. (PMID: 27596060)
Prog Lipid Res. 2020 Nov;80:101067. (PMID: 33011191)
Sci Rep. 2014 May 23;4:5013. (PMID: 24852694)
Diabetes Metab Res Rev. 2017 Nov;33(8):. (PMID: 28722798)
Int J Mol Sci. 2020 Aug 30;21(17):. (PMID: 32872570)
Cell. 2017 Jan 12;168(1-2):326. (PMID: 28038792)
J Trop Med. 2016;2016:7073894. (PMID: 27418933)

Keywords: Angiopoietin like 8; cardiometabolic risk factors; glucose; insulin; lipid profile; type 2 diabetes

0 (Angiopoietin-like Proteins)
0 (Angiopoietin-Like Protein 8)
0 (Biomarkers)
0 (ANGPTL8 protein, human)
0 (Blood Glucose)
9007-41-4 (C-Reactive Protein)
0 (Peptide Hormones)
0 (Triglycerides)
0 (Insulin)

Date Created: 20240606 Date Completed: 20240606 Latest Revision: 20240617

20240617

PMC11159548

10.1177/14791641241259792

38843864