Microbubble detection on ultrasound imaging by utilizing phase patterned waves.

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  • Author(s): An J;An J; Sugita N; Sugita N; Shinshi T; Shinshi T
  • Source:
    Physics in medicine and biology [Phys Med Biol] 2024 Jun 20; Vol. 69 (13). Date of Electronic Publication: 2024 Jun 20.
  • Publication Type:
    Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: IOP Publishing Country of Publication: England NLM ID: 0401220 Publication Model: Electronic Cited Medium: Internet ISSN: 1361-6560 (Electronic) Linking ISSN: 00319155 NLM ISO Abbreviation: Phys Med Biol Subsets: MEDLINE
    • Publication Information:
      Original Publication: Bristol : IOP Publishing
    • Subject Terms:
      Microbubbles* ; Ultrasonography*/methods ; Phantoms, Imaging*; Contrast Media/chemistry
    • Abstract:
      Objective. Super-resolution ultrasonography offers the advantage of visualization of intricate microvasculature, which is crucial for disease diagnosis. Mapping of microvessels is possible by localizing microbubbles (MBs) that act as contrast agents and tracking their location. However, there are limitations such as the low detectability of MBs and the utilization of a diluted concentration of MBs, leading to the extension of the acquisition time. We aim to enhance the detectability of MBs to reduce the acquisition time of acoustic data necessary for mapping the microvessels. Approach. We propose utilizing phase patterned waves (PPWs) characterized by spatially patterned phase distributions in the incident beam to achieve this. In contrast to conventional ultrasound irradiation methods, this irradiation method alters bubble interactions, enhancing the oscillation response of MBs and generating more significant scattered waves from specific MBs. This enhances the detectability of MBs, thereby enabling the detection of MBs that were undetectable by the conventional method. The objective is to maximize the overall detection of bubbles by utilizing ultrasound imaging with additional PPWs, including the conventional method. In this paper, we apply PPWs to ultrasound imaging simulations considering bubble-bubble interactions to elucidate the characteristics of PPWs and demonstrate their efficacy by employing PPWs on MBs fixed in a phantom by the experiment. Main results. By utilizing two types of PPWs in addition to the conventional ultrasound irradiation method, we confirmed the detection of up to 93.3% more MBs compared to those detected using the conventional method alone. Significance. Ultrasound imaging using additional PPWs made it possible to increase the number of detected MBs, which is expected to improve the efficiency of bubble detection.
      (© 2024 Institute of Physics and Engineering in Medicine.)
    • Contributed Indexing:
      Keywords: bubble detection; bubble oscillation; bubble–bubble interaction; phase-patterned ultrasound waves; super-resolution ultrasonography; ultrasound contrast agents
    • Accession Number:
      0 (Contrast Media)
    • Publication Date:
      Date Created: 20240606 Date Completed: 20240620 Latest Revision: 20240620
    • Publication Date:
      20240620
    • Accession Number:
      10.1088/1361-6560/ad5511
    • Accession Number:
      38843808