Dual-sensitized heterojunction Ag 2 S/ZnS/NiS composites with entire visible-light region absorption for ultrasensitive photoelectrochemical detection of tobramycin.

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  • Additional Information
    • Source:
      Publisher: Elsevier Advanced Technology Country of Publication: England NLM ID: 9001289 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4235 (Electronic) Linking ISSN: 09565663 NLM ISO Abbreviation: Biosens Bioelectron Subsets: MEDLINE
    • Publication Information:
      Publication: Oxford : Elsevier Advanced Technology
      Original Publication: [Barking, Essex, England] : Elsevier Applied Science, 1989-
    • Subject Terms:
      Biosensing Techniques* ; Tobramycin*/analysis ; Tobramycin*/chemistry ; Electrochemical Techniques*/methods ; Limit of Detection* ; Aptamers, Nucleotide*/chemistry ; Silver Compounds*/chemistry ; Zinc Compounds*/chemistry ; Sulfides*/chemistry ; Milk*/chemistry ; Light*; Animals ; Metal Nanoparticles/chemistry ; Anti-Bacterial Agents/analysis ; Gold/chemistry ; Food Contamination/analysis
    • Abstract:
      In this study, an ultrasensitive photoelectrochemical (PEC) aptasensor based on dual-sensitized heterojunction Ag 2 S/ZnS/NiS composites as a signal probe was proposed for the detection of tobramycin (TOB) by combining a cascaded quadratic signal amplification strategy. Specifically, compared to the limited visible light-harvesting capability of single sensitized composites, Ag 2 S/ZnS/NiS composites with p-n and n-n heterojunction could greatly improve the light energy utilization to tremendously strengthen the optical absorption in the entire visible-light region. Moreover, dual-sensitized heterojunction could effectively hinder the rapid recombination of photoelectrons and holes (carriers) to obtain a good photocurrent for improving the sensitivity of the aptasensor. Furthermore, a cascaded quadratic signal amplification strategy was applied to convert trace target TOB into plentiful gold nanoclusters (Au NCs) labelled double-stranded DNA for the construction of PEC aptasensor, with a broad linear detection range from 0.01 to 100 ng mL -1 and a low detection limit of 3.38 pg mL -1 . Importantly, this study provided a versatile and sensitive PEC biosensing platform for TOB analysis, and demonstrated its successful application for TOB detection in milk samples. This protocol provides a novel dual-sensitized heterojunction composites to develop a highly efficient and harmfulless PEC aptasensor, which is expected to be used in food safety, environmental monitoring and other areas.
      Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
      (Copyright © 2024 Elsevier B.V. All rights reserved.)
    • Contributed Indexing:
      Keywords: Antibiotic detection; Cascaded quadratic signal amplification; Dual-sensitized heterojunction; Photoelectrochemical aptasensor
    • Accession Number:
      VZ8RRZ51VK (Tobramycin)
      0 (Aptamers, Nucleotide)
      0 (Silver Compounds)
      0 (Zinc Compounds)
      0 (Sulfides)
      KPS085631O (zinc sulfide)
      9ZB10YHC1C (silver sulfide)
      0 (Anti-Bacterial Agents)
      7440-57-5 (Gold)
    • Publication Date:
      Date Created: 20240605 Date Completed: 20240613 Latest Revision: 20240613
    • Publication Date:
      20240614
    • Accession Number:
      10.1016/j.bios.2024.116459
    • Accession Number:
      38838575