Sex difference in skeletal muscle mass in relation to metabolic dysfunction-associated steatotic liver disease: a propensity score matching study.

Publisher: Elsevier Masson SAS on behalf of SERDI Publisher Country of Publication: France NLM ID: 100893366 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1760-4788 (Electronic) Linking ISSN: 12797707 NLM ISO Abbreviation: J Nutr Health Aging Subsets: MEDLINE

Publication: 2024- : [Paris, France] : Elsevier Masson SAS on behalf of SERDI Publisher
Original Publication: Paris, France : New York, NY : Serdi Publisher ; Springer Pub. Co.,

Propensity Score* ; Muscle, Skeletal* ; Non-alcoholic Fatty Liver Disease*/epidemiology ; Nutrition Surveys*; Humans ; Male ; Female ; Republic of Korea/epidemiology ; Middle Aged ; Sex Factors ; Risk Factors ; Adult ; Sarcopenia/epidemiology ; Sarcopenia/complications ; Prevalence ; Aged ; Cross-Sectional Studies

Background: While low muscle mass is considered a risk factor for metabolic dysfunction-associated steatotic liver disease (MASLD), whether the relationship is independent of fat mass remains unclear.
Objectives: This study aims to clarify the association between the sex-specific height-adjusted low skeletal muscle mass index (LSMI) and MASLD.
Methods: Data from the 2008-2010 Korean National Health and Nutrition Examination Survey were analyzed. LSMI was defined using the 2019 Asian Working Group for Sarcopenia. The non-alcoholic fatty liver disease-liver fat score was used to assess MASLD. Gender-specific 1:1 propensity score matching (PSM) was performed to mitigate the confounding effects of anthropometric variables and lifestyles. Conditional logistic analysis was used on the dataset after PSM to estimate the odds ratio (OR) with a 95% confidence interval (CI).
Results: After PSM, the prevalence of MASLD was significantly higher in men with LSMI than in those without LSMI (37.4% vs. 29.6%). No significant difference was observed in the prevalence of MASLD between groups after PSM in women (20.4% vs. 20.3%). Conditional logistic analysis revealed that the odds of having MASLD were significantly higher in men with LSMI compared to those without LSMI (OR = 1.38, 95% CI: 1.09-1.75), while no significant association was found in women with LSMI (OR = 1.10, 95% CI: 0.87-1.40).
Conclusion: Height-adjusted LSMI is an independent factor associated with MASLD in the condition of the same level of fat mass in men. Further prospective studies in diverse populations are needed to confirm our findings.
(Copyright © 2024 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)

Keywords: Chronic liver disease; Low skeletal muscle mass; Metabolic dysfunction-associated steatotic liver disease; Propensity score matching

Date Created: 20240604 Date Completed: 20240614 Latest Revision: 20240615

20240615

10.1016/j.jnha.2024.100270

38833877