Highly efficient prevention of radiation dermatitis using a PEGylated superoxide dismutase dissolving microneedle patch.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Additional Information
    • Source:
      Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 9109778 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3441 (Electronic) Linking ISSN: 09396411 NLM ISO Abbreviation: Eur J Pharm Biopharm Subsets: MEDLINE
    • Publication Information:
      Publication: Amsterdam : Elsevier Science
      Original Publication: Stuttgart : Wissenschaftliche Verlagsgesellschaft, c1991-
    • Subject Terms:
      Polyethylene Glycols*/chemistry ; Superoxide Dismutase*/metabolism ; Superoxide Dismutase*/administration & dosage ; Needles* ; Skin*/metabolism ; Skin*/drug effects ; Skin*/radiation effects ; Administration, Cutaneous* ; Radiodermatitis*/prevention & control ; Transdermal Patch* ; Skin Absorption*/drug effects; Animals ; Mice ; Male ; Radiation-Protective Agents/administration & dosage ; Radiation-Protective Agents/pharmacology ; Radiation-Protective Agents/pharmacokinetics
    • Abstract:
      PEGylated superoxide dismutase (PEG-SOD) is commonly used as a cytoprotective agent in radiotherapy. However, its effectiveness in preventing radiation dermatitis is limited owing to its poor skin permeability. To address this issue, a PEG-SOD-loaded dissolving microneedle (PSMN) patch was developed to effectively prevent radiation dermatitis. Initially, PSMN patches were fabricated using a template mold method with polyvinylpyrrolidone K90 as the matrix material. PSMNs exhibited a conical shape with adequate mechanical strength to penetrate the stratum corneum. More than 90 % of PEG-SOD was released from the PSMN patches within 30 min. Notably, the PSMN patches showed a significantly higher drug skin permeation than the PEG-SOD solutions, with a 500-fold increase. In silico simulations and experiments on skin pharmacokinetics confirmed that PSMN patches enhanced drug permeation and skin absorption, in contrast to PEG-SOD solutions. More importantly, PSMN patches efficiently mitigated ionizing radiation-induced skin damage, accelerated the healing process of radiation-affected skin tissues, and exhibited highly effective radioprotective activity for DNA in the skin tissue. Therefore, PSMN patches are promising topical remedy for the prevention of radiation dermatitis.
      Competing Interests: Declaration of Competing Interest The authors declared no conflicts of interest regarding this study.
      (Copyright © 2024 Elsevier B.V. All rights reserved.)
    • Contributed Indexing:
      Keywords: Ionizing radiation; Microneedles; PEGylated superoxide dismutase; Radiation dermatitis; Transdermal delivery
    • Accession Number:
      3WJQ0SDW1A (Polyethylene Glycols)
      EC 1.15.1.1 (Superoxide Dismutase)
      0 (Radiation-Protective Agents)
    • Publication Date:
      Date Created: 20240602 Date Completed: 20240711 Latest Revision: 20240807
    • Publication Date:
      20240807
    • Accession Number:
      10.1016/j.ejpb.2024.114347
    • Accession Number:
      38825168