The human major sublingual gland and its neuropeptidergic and nitrergic innervations.

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  • Additional Information
    • Source:
      Publisher: G. Fischer Country of Publication: Germany NLM ID: 100963897 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-0402 (Electronic) Linking ISSN: 09409602 NLM ISO Abbreviation: Ann Anat Subsets: MEDLINE
    • Publication Information:
      Original Publication: Jena [Germany] ; New York : G. Fischer, c1992-
    • Subject Terms:
      Sublingual Gland*/innervation ; Sublingual Gland*/metabolism ; Neuropeptides*/metabolism ; Substance P*/metabolism; Humans ; Male ; Female ; Neuropeptide Y/metabolism ; Calcitonin Gene-Related Peptide/metabolism ; Vasoactive Intestinal Peptide/metabolism ; Immunohistochemistry ; Middle Aged ; Nitric Oxide Synthase Type I/metabolism ; Aged ; Adult ; Aged, 80 and over
    • Abstract:
      Background: What textbooks usually call the sublingual gland in humans is in reality a tissue mass of two types of salivary glands, the anteriorly located consisting of a cluster of minor sublingual glands and the posteriorly located major sublingual gland with its outlet via Bartholin's duct. Only recently, the adrenergic and cholinergic innervations of the major sublingual gland was reported, while information regarding the neuropeptidergic and nitrergic innervations is still lacking.
      Methods: Bioptic and autoptic specimens of the human major sublingual gland were examined by means of immunohistochemistry for the presence of vasoactive intestinal peptide (VIP)-, neuropeptide Y (NPY)-, substance P (SP)-, calcitonin gene related-peptide (CGRP)-, and neuronal nitric oxide synthase (nNOS)-labeled neuronal structures.
      Results: As to the neuropeptidergic innervation of secretory cells (here in the form of mucous tubular and seromucous cells), the findings showed many VIP-containing nerves, few NPY- and SP-containing nerves and a lack of CGRP-labeled nerves. As to the neuropeptidergic innervation of vessels, the number of VIP-containing nerves was modest, while, of the other neuropeptide-containing nerves under study, only few (SP and CGRP) to very few (NPY) nerves were observed. As to the nitrergic innervation, nNOS-containing nerves were very few close to secretory cells and even absent around vessels.
      Conclusion: The various innervation patterns may suggest potential transmission mechanisms involved in secretory and vascular responses of the major sublingual gland.
      Competing Interests: Declaration of Competing Interest None.
      (Copyright © 2024 The Authors. Published by Elsevier GmbH.. All rights reserved.)
    • Contributed Indexing:
      Keywords: Calcitonin gene related peptide; Human major sublingual gland; Immunohistochemistry; Neuronal nitric oxide synthase; Neuropeptide Y; Substance P; Vasoactive intestinal peptide
    • Accession Number:
      0 (Neuropeptides)
      33507-63-0 (Substance P)
      0 (Neuropeptide Y)
      JHB2QIZ69Z (Calcitonin Gene-Related Peptide)
      37221-79-7 (Vasoactive Intestinal Peptide)
      EC 1.14.13.39 (Nitric Oxide Synthase Type I)
    • Publication Date:
      Date Created: 20240531 Date Completed: 20240720 Latest Revision: 20240720
    • Publication Date:
      20240722
    • Accession Number:
      10.1016/j.aanat.2024.152291
    • Accession Number:
      38821428