A step toward simplified dosimetry of radiopharmaceutical therapy via SPECT frame duration reduction.

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  • Additional Information
    • Source:
      Publisher: Pergamon Press Country of Publication: England NLM ID: 9306253 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9800 (Electronic) Linking ISSN: 09698043 NLM ISO Abbreviation: Appl Radiat Isot Subsets: MEDLINE
    • Publication Information:
      Original Publication: Oxford ; New York : Pergamon Press, c1993-
    • Subject Terms:
      Radiopharmaceuticals*/therapeutic use ; Monte Carlo Method* ; Prostatic Neoplasms, Castration-Resistant*/radiotherapy ; Prostatic Neoplasms, Castration-Resistant*/diagnostic imaging ; Tomography, Emission-Computed, Single-Photon*/methods ; Radiometry*/methods; Humans ; Male ; Lutetium/therapeutic use ; Calibration ; Radiotherapy Dosage ; Radioisotopes
    • Abstract:
      Despite being time-consuming, SPECT/CT data is necessary for accurate dosimetry in patient-specific radiopharmaceutical therapy. We investigated how reducing the frame duration (FD) during SPECT acquisition can simplify the dosimetry workflow for [ 177 Lu]Lu-PSMA radioligand therapy (RLT). We aimed to determine the impact of shortened acquisition times on dosimetric precision. Three SPECT scans with FD of 20, 10, and 5 second/frame (sec/fr) were obtained 48 h post-RLT from one metastatic castration-resistant prostate cancer (mCRPC) patient's pelvis. Planar images at 4, 48, and 72 h post-therapy were used to calculate time-integrated activities (TIAs). Using accurate activity calibrations and GATE Monte Carlo (MC) dosimetry, absorbed doses in tumor lesions and kidneys were estimated. Dosimetry precision was assessed by comparing shorter FD results to the 20 sec/fr reference using relative percentage difference (RPD). We observed consistent calibration factors (CFs) across different FDs. Using the same CF, we obtained marginal RPD deviations less than 4% for the right kidney and tumor lesions and less than 7% for the left kidney. By reducing FD, simulation time was slightly decreased. This study shows we can shorten SPECT acquisition time in RLT dosimetry by reducing FD without sacrificing dosimetry accuracy. These findings pave the way for streamlined personalized internal dosimetry workflows.
      Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
      (Copyright © 2024 Elsevier Ltd. All rights reserved.)
    • Contributed Indexing:
      Keywords: (177)Lu-PSMA; Acquisition time; Frame duration; Internal dosimetry; Prostate cancer; Radiopharmaceutical; SPECT
    • Accession Number:
      0 (Radiopharmaceuticals)
      5H0DOZ21UJ (Lutetium)
      BRH40Y9V1Q (Lutetium-177)
      0 (Radioisotopes)
    • Publication Date:
      Date Created: 20240531 Date Completed: 20240611 Latest Revision: 20240611
    • Publication Date:
      20240612
    • Accession Number:
      10.1016/j.apradiso.2024.111378
    • Accession Number:
      38820867