Candida auris from the Egyptian cobra: Role of snakes as potential reservoirs.

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  • Additional Information
    • Source:
      Publisher: Oxford University Press Country of Publication: England NLM ID: 9815835 Publication Model: Print Cited Medium: Internet ISSN: 1460-2709 (Electronic) Linking ISSN: 13693786 NLM ISO Abbreviation: Med Mycol Subsets: MEDLINE
    • Publication Information:
      Publication: 2014- : Oxford : Oxford University Press
      Original Publication: Oxford : Blackwell Science, c1998-
    • Subject Terms:
      Candida*/genetics ; Candida*/classification ; Candida*/isolation & purification ; Candida*/drug effects ; Disease Reservoirs*/microbiology ; Candidiasis*/microbiology ; Candidiasis*/veterinary ; DNA, Ribosomal Spacer*/genetics ; DNA, Ribosomal Spacer*/chemistry; Animals ; Cloaca/microbiology ; Sequence Analysis, DNA ; DNA, Fungal/genetics ; Blood/microbiology ; Snakes/microbiology ; Elapidae ; Egypt ; Phylogeny
    • Abstract:
      Candida auris represents one of the most urgent threats to public health, although its ecology remains largely unknown. Because amphibians and reptiles may present favorable conditions for C. auris colonization, cloacal and blood samples (n = 68), from several snake species, were cultured and molecularly screened for C. auris using molecular amplification of glycosylphosphatidylinositol protein-encoding genes and ribosomal internal transcribed spacer sequencing. Candida auris was isolated from the cloacal swab of one Egyptian cobra (Naja haje legionis) and molecularly identified in its cloaca and blood. The isolation of C. auris from wild animals is herein reported for the first time, thus suggesting the role that these animals could play as reservoirs of this emerging pathogen. The occurrence of C. auris in blood requires further investigation, although the presence of cationic antimicrobial peptides in the plasma of reptiles could play a role in reducing the vitality of the fungus.
      (© The Author(s) 2024. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology.)
    • Contributed Indexing:
      Keywords: Candida auris; antifungal resistance; glycosylphosphatidylinositol (GPI) protein-encoding genes; ribosomal internal transcribed spacer (ITS); snake
      Local Abstract: [plain-language-summary] Candida auris represents one of the most urgent threats to public health. In this study, we reported for the first time the isolation of C. auris from snake thus suggesting the role of these animals as reservoirs of this emerging pathogen.
    • Accession Number:
      0 (DNA, Ribosomal Spacer)
      0 (DNA, Fungal)
    • Publication Date:
      Date Created: 20240530 Date Completed: 20240704 Latest Revision: 20240706
    • Publication Date:
      20240706
    • Accession Number:
      10.1093/mmy/myae056
    • Accession Number:
      38816207