Chemoselective Proteomics, Zinc Fingers, and a Zinc(II) Model for H 2 S Mediated Persulfidation.

Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: MEDLINE

Publication: <2004-> : Weinheim : Wiley-VCH
Original Publication: Weinheim/Bergstr. : New York, : Verlag Chemie ; Academic Press, c1962-

Hydrogen Sulfide*/chemistry ; Hydrogen Sulfide*/metabolism ; Zinc*/chemistry ; Zinc Fingers* ; Proteomics* ; Sulfides*/chemistry; Humans ; Protein Processing, Post-Translational

The gasotransmitter hydrogen sulfide (H 2 S) is thought to be involved in the post-translational modification of cysteine residues to produce reactive persulfides. A persulfide-specific chemoselective proteomics approach with mammalian cells has identified a broad range of zinc finger (ZF) proteins as targets of persulfidation. Parallel studies with isolated ZFs show that persulfidation is mediated by Zn ^II , O 2 , and H 2 S, with intermediates involving oxygen- and sulfur-based radicals detected by mass spectrometry and optical spectroscopies. A small molecule Zn ^II complex exhibits analogous reactivity with H 2 S and O 2 , giving a persulfidated product. These data show that Zn ^II is not just a biological structural element, but also plays a critical role in mediating H 2 S-dependent persulfidation. ZF persulfidation appears to be a general post-translational modification and a possible conduit for H 2 S signaling. This work has implications for our understanding of H 2 S-mediated signaling and the regulation of ZFs in cellular physiology and development.
(© 2024 Wiley-VCH GmbH.)

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R01 GM139854 United States GM NIGMS NIH HHS; R35 GM149233 United States GM NIGMS NIH HHS; R35GM149233 United States NH NIH HHS; R01GM139854 United States NH NIH HHS

Keywords: hydrogen sulfide; persulfidation; proteomics; small molecules; zinc finger proteins

YY9FVM7NSN (Hydrogen Sulfide)
J41CSQ7QDS (Zinc)
0 (persulfides)
0 (Sulfides)

Date Created: 20240529 Date Completed: 20240626 Latest Revision: 20240827

20240827

PMC11346292

10.1002/anie.202401003

38808693