Plasma Biomarkers in Neurodegenerative Dementias: Unrevealing the Potential of Serum Oxytocin, BDNF, NPTX1, TREM2, TNF-alpha, IL-1 and Prolactin.

Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 101208441 Publication Model: Print Cited Medium: Internet ISSN: 1875-5828 (Electronic) Linking ISSN: 15672050 NLM ISO Abbreviation: Curr Alzheimer Res Subsets: MEDLINE

Original Publication: Saif Zone, Sharjah, U.A.E. ; San Francisco, CA : Bentham Science Publishers, c2004-

Receptors, Immunologic*/blood ; Prolactin*/blood ; Biomarkers*/blood ; Brain-Derived Neurotrophic Factor*/blood ; Tumor Necrosis Factor-alpha*/blood ; Membrane Glycoproteins*/blood ; Nerve Tissue Proteins*/blood ; Oxytocin*/blood; Humans ; Female ; Male ; Aged ; Lewy Body Disease/blood ; Lewy Body Disease/diagnosis ; Interleukin-1/blood ; Middle Aged ; Alzheimer Disease/blood ; Alzheimer Disease/diagnosis ; Frontotemporal Dementia/blood ; Frontotemporal Dementia/diagnosis ; Aged, 80 and over ; Neurodegenerative Diseases/blood ; Neurodegenerative Diseases/diagnosis ; C-Reactive Protein

Background: Dementia encompasses a range of neurodegenerative disorders characterized by cognitive decline and functional impairment. The identification of reliable biomarkers is essential for accurate diagnosis and gaining insights into the mechanisms underlying diseases.
Objective: This study aimed to investigate the plasma biomarker profiles associated with Brain- Derived Neurotrophic Factor (BDNF), Oxytocin, Neuronal Pentraxin-1 (NPTX1), Triggering Receptor Expressed on Myeloid Cells 2 (TREM2), Tumor Necrosis Factor-alpha (TNF-alpha), Interleukin- 1 (IL-1) and Prolactin in Alzheimer's disease (AD), dementia with Lewy bodies (DLB), frontotemporal dementias (FTD) and healthy controls.
Methods: Serum levels of the aforementioned biomarkers were analyzed in 23 AD, 28 DLB, 15 FTD patients recruited from outpatient units and 22 healthy controls. Diagnostic evaluations followed established criteria and standardized clinical tests were conducted. Blood samples were collected and analyzed using ELISA and electrochemiluminescence immunoassay methods.
Results: Serum BDNF and oxytocin levels did not significantly differ across groups. NPTX1, TREM2, TNF-alpha and IL-1 levels also did not show significant differences among dementia groups. However, prolactin levels exhibited distinct patterns, with lower levels in male DLB patients and higher levels in female AD patients compared to controls.
Conclusion: The study findings suggest potential shared mechanisms in dementia pathophysiology and highlight the importance of exploring neuroendocrine responses, particularly in AD and DLB. However, further research is warranted to elucidate the role of these biomarkers in dementia diagnosis and disease progression.
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37023,35895 Istanbul Üniversitesi

Keywords: Alzheimer's disease; BDNF; IL-1; NPTX1; TNF-alpha.; TREM2; dementia with Lewy bodies; frontotemporal dementia; oxytocin; prolactin; serum biomarker

0 (Receptors, Immunologic)
9002-62-4 (Prolactin)
0 (Biomarkers)
0 (Brain-Derived Neurotrophic Factor)
0 (Tumor Necrosis Factor-alpha)
0 (neuronal pentraxin)
0 (Membrane Glycoproteins)
0 (Nerve Tissue Proteins)
50-56-6 (Oxytocin)
0 (TREM2 protein, human)
0 (Interleukin-1)
7171WSG8A2 (BDNF protein, human)
9007-41-4 (C-Reactive Protein)

Date Created: 20240528 Date Completed: 20240827 Latest Revision: 20241004

20241004

10.2174/0115672050313419240520051751

38803182