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Geraniol mitigates anxiety-like behaviors in rats by reducing oxidative stress, repairing impaired hippocampal neurotransmission, and normalizing brain cortical-EEG wave patterns after a single electric foot-shock exposure.
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- Author(s): Nisar R;Nisar R; Inamullah A; Inamullah A; Ghalib AUF; Ghalib AUF; Nisar H; Nisar H; Sarkaki A; Sarkaki A; Afzal A; Afzal A; Tariq M; Tariq M; Batool Z; Batool Z; Haider S; Haider S
- Source:
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2024 Jul; Vol. 176, pp. 116771. Date of Electronic Publication: 2024 May 24.- Publication Type:
Journal Article- Language:
English - Source:
- Additional Information
- Source: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1950-6007 (Electronic) Linking ISSN: 07533322 NLM ISO Abbreviation: Biomed Pharmacother Subsets: MEDLINE
- Publication Information: Publication: Paris : Editions Scientifiques Elsevier
Original Publication: New York, N.Y. : Masson Pub. USA, Inc., c1982- - Subject Terms: Acyclic Monoterpenes*/pharmacology ; Oxidative Stress*/drug effects ; Anxiety*/drug therapy ; Hippocampus*/drug effects ; Hippocampus*/metabolism ; Rats, Wistar* ; Anti-Anxiety Agents*/pharmacology ; Electroencephalography* ; Synaptic Transmission*/drug effects ; Behavior, Animal*/drug effects; Animals ; Male ; Rats ; Electroshock ; Antioxidants/pharmacology ; Terpenes/pharmacology ; Diazepam/pharmacology ; Disease Models, Animal ; Brain Waves/drug effects
- Abstract: Anxiety-like conditions can interfere with daily activities as the adaptive mechanism fails to cope with stress. These conditions are often linked with increased oxidative stress, and abrupt neurotransmission and electroencephalography (EEG) wave pattern. Geraniol, a monoterpenoid, has antioxidant and anti-inflammatory activities, as well as brain-calming effects. Therefore, in this study, geraniol was tested for the potential anxiolytic effects in a rat model of anxiety. The rats were exposed to an electric foot shock (1 mA for 1 s) to develop anxiety-like symptoms. Treatment was carried out using geraniol (10 and 30 mg/kg) and the standard diazepam drug. The behavior of the rats was analyzed using the open field test, light-dark test, and social interaction test. Afterward, the rats were decapitated to collect samples for neurochemical and biochemical analyses. The cortical-EEG wave pattern was also obtained. The study revealed that the electric foot shock induced anxiety-like symptoms, increased oxidative stress, and altered hippocampal neurotransmitter levels. The power of low-beta and high-beta was amplified with the increased coupling of delta-beta waves in anxiety group. However, the treatment with geraniol and diazepam normalized cortical-EEG wave pattern and hippocampal serotonin and catecholamines profile which was also reflected by reduced anxious behavior and normalized antioxidant levels. The study reports an anxiolytic potential of geraniol, which can be further explored in future.
Competing Interests: Declaration of Competing Interest The authors have no conflicts of interest to disclose.
(Copyright © 2024 The Authors. Published by Elsevier Masson SAS.. All rights reserved.) - Contributed Indexing: Keywords: 5-HT; Anxiety; Cortical-EEG; Delta-beta coupling; Dopamine; Geraniol
- Accession Number: 0 (Acyclic Monoterpenes)
L837108USY (geraniol)
0 (Anti-Anxiety Agents)
0 (Antioxidants)
0 (Terpenes)
Q3JTX2Q7TU (Diazepam) - Publication Date: Date Created: 20240525 Date Completed: 20240619 Latest Revision: 20240619
- Publication Date: 20240619
- Accession Number: 10.1016/j.biopha.2024.116771
- Accession Number: 38795639
- Source:
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