Toward a Categorization of Virus-ncRNA Interactions in the World of RNA to Disentangle the Tiny Secrets of Dengue Virus.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915 (Electronic) Linking ISSN: 19994915 NLM ISO Abbreviation: Viruses Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI

Dengue Virus*/genetics ; Dengue Virus*/physiology ; RNA, Untranslated*/genetics ; RNA, Untranslated*/metabolism ; RNA, Viral*/genetics ; RNA, Viral*/metabolism ; Genome, Viral*; Humans ; Host-Pathogen Interactions/genetics ; Dengue/virology ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Animals

In recent years, the function of noncoding RNAs (ncRNAs) as regulatory molecules of cell physiology has begun to be better understood. Advances in viral molecular biology have shown that host ncRNAs, cellular factors, and virus-derived ncRNAs and their interplay are strongly disturbed during viral infections. Nevertheless, the folding of RNA virus genomes has also been identified as a critical factor in regulating canonical and non-canonical functions. Due to the influence of host ncRNAs and the structure of RNA viral genomes, complex molecular and cellular processes in infections are modulated. We propose three main categories to organize the current information about RNA-RNA interactions in some well-known human viruses. The first category shows examples of host ncRNAs associated with the immune response triggered in viral infections. Even though miRNAs introduce a standpoint, they are briefly presented to keep researchers moving forward in uncovering other RNAs. The second category outlines interactions between virus-host ncRNAs, while the third describes how the structure of the RNA viral genome serves as a scaffold for processing virus-derived RNAs. Our grouping may provide a comprehensive framework to classify ncRNA-host-cell interactions for emerging viruses and diseases. In this sense, we introduced them to organize DENV-host-cell interactions.

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Keywords: DENV; immune response; microRNAs; ncRNAs; sfRNAs; virus–host cell interactions

0 (RNA, Untranslated)
0 (RNA, Viral)
0 (MicroRNAs)

Date Created: 20240525 Date Completed: 20240525 Latest Revision: 20240528

20240528

PMC11125801

10.3390/v16050804

38793685