An Isotonic Drink Containing Pacific Cod ( Gadus macrocephalus ) Processing Waste Collagen Hydrolysate for Bone and Cartilage Health.

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  • Additional Information
    • Source:
      Publisher: MDPI Country of Publication: Switzerland NLM ID: 101213729 Publication Model: Electronic Cited Medium: Internet ISSN: 1660-3397 (Electronic) Linking ISSN: 16603397 NLM ISO Abbreviation: Mar Drugs Subsets: MEDLINE
    • Publication Information:
      Original Publication: Basel, Switzerland : MDPI, [2003]-
    • Subject Terms:
      Gadiformes* ; Collagen*/metabolism ; Cartilage*/drug effects ; Cartilage*/metabolism ; Bone and Bones*/drug effects ; Bone and Bones*/metabolism ; Protein Hydrolysates*/pharmacology ; Protein Hydrolysates*/chemistry; Animals ; Humans ; Mesenchymal Stem Cells/drug effects ; Beverages ; Functional Food ; Hydrolysis
    • Abstract:
      Malnutrition is one of the major factors of bone and cartilage disorders. Pacific cod ( Gadus macrocephalus ) processing waste is a cheap and highly promising source of bioactive substances, including collagen-derived peptides and amino acids, for bone and cartilage structure stabilization. The addition of these substances to a functional drink is one of the ways to achieve their fast intestinal absorption. Collagen hydrolysate was obtained via enzymatic hydrolysis, ultrafiltration, freeze-drying, and grinding to powder. The lyophilized hydrolysate was a light gray powder with high protein content (>90%), including collagen (about 85% of total protein) and a complete set of essential and non-essential amino acids. The hydrolysate had no observed adverse effect on human mesenchymal stem cell morphology, viability, or proliferation. The hydrolysate was applicable as a protein food supply or a structure-forming food component due to the presence of collagen fiber fragments. An isotonic fitness drink (osmolality 298.1 ± 2.1 mOsm/L) containing hydrolysate and vitamin C as a cofactor in collagen biosynthesis was prepared. The addition of the hydrolysate did not adversely affect its organoleptic parameters. The production of such functional foods and drinks is one of the beneficial ways of fish processing waste utilization.
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    • Contributed Indexing:
      Keywords: Pacific cod; bioactive substances; bone and cartilage health; collagen hydrolysate; isotonic drink; processing waste utilization
    • Accession Number:
      9007-34-5 (Collagen)
      0 (Protein Hydrolysates)
    • Publication Date:
      Date Created: 20240524 Date Completed: 20240524 Latest Revision: 20240526
    • Publication Date:
      20240526
    • Accession Number:
      PMC11122821
    • Accession Number:
      10.3390/md22050202
    • Accession Number:
      38786592