Menu
×
West Ashley Library
Closed (2024 - Labor Day)
Phone: (843) 766-6635
Folly Beach Library
Closed (2024 - Labor Day)
Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
Closed (2024 - Labor Day)
Phone: (843) 883-3914
Wando Mount Pleasant Library
Closed (2024 - Labor Day)
Phone: (843) 805-6888
Village Library
Closed (2024 - Labor Day)
Phone: (843) 884-9741
St. Paul's/Hollywood Library
Closed (2024 - Labor Day)
Phone: (843) 889-3300
Otranto Road Library
Closed (2024 - Labor Day)
Phone: (843) 572-4094
Mt. Pleasant Library
Closed (2024 - Labor Day)
Phone: (843) 849-6161
McClellanville Library
Closed (2024 - Labor Day)
Phone: (843) 887-3699
Keith Summey North Charleston Library
Closed (2024 - Labor Day)
Phone: (843) 744-2489
John's Island Library
Closed (2024 - Labor Day)
Phone: (843) 559-1945
Hurd/St. Andrews Library
Closed (2024 - Labor Day)
Phone: (843) 766-2546
Miss Jane's Building (Edisto Library Temporary Location)
Closed (2024 - Labor Day)
Phone: (843) 869-2355
Dorchester Road Library
Closed (2024 - Labor Day)
Phone: (843) 552-6466
John L. Dart Library
Closed (2024 - Labor Day)
Phone: (843) 722-7550
Baxter-Patrick James Island
Closed (2024 - Labor Day)
Phone: (843) 795-6679
Main Library
Closed (2024 - Labor Day)
Phone: (843) 805-6930
Bees Ferry West Ashley Library
Closed (2024 - Labor Day)
Phone: (843) 805-6892
Mobile Library
Closed (2024 - Labor Day)
Phone: (843) 805-6909
Today's Hours
West Ashley Library
Closed (2024 - Labor Day)
Phone: (843) 766-6635
Folly Beach Library
Closed (2024 - Labor Day)
Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
Closed (2024 - Labor Day)
Phone: (843) 883-3914
Wando Mount Pleasant Library
Closed (2024 - Labor Day)
Phone: (843) 805-6888
Village Library
Closed (2024 - Labor Day)
Phone: (843) 884-9741
St. Paul's/Hollywood Library
Closed (2024 - Labor Day)
Phone: (843) 889-3300
Otranto Road Library
Closed (2024 - Labor Day)
Phone: (843) 572-4094
Mt. Pleasant Library
Closed (2024 - Labor Day)
Phone: (843) 849-6161
McClellanville Library
Closed (2024 - Labor Day)
Phone: (843) 887-3699
Keith Summey North Charleston Library
Closed (2024 - Labor Day)
Phone: (843) 744-2489
John's Island Library
Closed (2024 - Labor Day)
Phone: (843) 559-1945
Hurd/St. Andrews Library
Closed (2024 - Labor Day)
Phone: (843) 766-2546
Miss Jane's Building (Edisto Library Temporary Location)
Closed (2024 - Labor Day)
Phone: (843) 869-2355
Dorchester Road Library
Closed (2024 - Labor Day)
Phone: (843) 552-6466
John L. Dart Library
Closed (2024 - Labor Day)
Phone: (843) 722-7550
Baxter-Patrick James Island
Closed (2024 - Labor Day)
Phone: (843) 795-6679
Main Library
Closed (2024 - Labor Day)
Phone: (843) 805-6930
Bees Ferry West Ashley Library
Closed (2024 - Labor Day)
Phone: (843) 805-6892
Mobile Library
Closed (2024 - Labor Day)
Phone: (843) 805-6909
Patron Login
menu
Item request has been placed!
×
Item request cannot be made.
×
![loading](/sites/all/modules/hf_eds/images/loading.gif)
mNGS helped diagnose scrub typhus-associated HLH in children: a report of two cases.
Item request has been placed!
×
Item request cannot be made.
×
![loading](/sites/all/modules/hf_eds/images/loading.gif)
- Author(s): Jian H;Jian H;Jian H; Yang QX; Yang QX; Yang QX; Duan JX; Duan JX; Duan JX; Lai SY; Lai SY; Lai SY; Che GL; Che GL; Che GL; Teng J; Teng J; Teng J; Chang L; Chang L; Chang L; Liu XJ; Liu XJ; Liu XJ; Luo LL; Luo LL; Luo LL; Liu F; Liu F; Liu F
- Source:
Frontiers in public health [Front Public Health] 2024 May 09; Vol. 12, pp. 1321123. Date of Electronic Publication: 2024 May 09 (Print Publication: 2024).- Publication Type:
Case Reports; Journal Article- Language:
English - Source:
- Additional Information
- Source: Publisher: Frontiers Editorial Office Country of Publication: Switzerland NLM ID: 101616579 Publication Model: eCollection Cited Medium: Internet ISSN: 2296-2565 (Electronic) Linking ISSN: 22962565 NLM ISO Abbreviation: Front Public Health Subsets: MEDLINE
- Publication Information: Original Publication: Lausanne : Frontiers Editorial Office
- Subject Terms:
- Abstract: Background: Scrub typhus, caused by the Orientia tsutsugamushi (Ot) , is a widespread vector-borne disease transmitted by chigger mites. Hemophagocytic lymphohistiocytosis (HLH) is considered to be one of the potentially severe complications. The diagnosis of scrub typhus-associated HLH may be overlooked due to the non-specific clinical characteristics and the absence of pathognomonic eschar.
Case Presentation: We obtained clinical data from two patients in the South of Sichuan, China. The first case involved a 6-year-old girl who exhibited an unexplained fever and was initially diagnosed with sepsis, HLH, and pulmonary infection. The other patient presented a more severe condition characterized by multiple organ dysfunction and was initially diagnosed with septic shock, sepsis, HLH, acute kidney injury (AKI), and pulmonary infection. At first, a specific examination for scrub typhus was not performed due to the absence of a characteristic eschar. Conventional peripheral blood cultures yielded negative results in both patients, and neither of them responded to routine antibiotics. Fortunately, the causative pathogen Orientia tsutsugamushi (Ot) was detected in the plasma samples of both patients using metagenomics next-generation sequencing (mNGS) and further confirmed by polymerase chain reaction. Subsequently, they both were treated with doxycycline and recovered quickly.
Conclusion: The unbiased mNGS provided a clinically actionable diagnosis for an uncommon pathogen-associated infectious disease that had previously evaded conventional diagnostic approaches.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2024 Jian, Yang, Duan, Lai, Che, Teng, Chang, Liu, Luo and Liu.) - References: BMC Infect Dis. 2021 Dec 7;21(1):1219. (PMID: 34876034)
N Engl J Med. 2016 Sep 8;375(10):954-61. (PMID: 27602667)
Haematologica. 2004 Feb;89(2):183-8. (PMID: 15003893)
World J Crit Care Med. 2015 Aug 04;4(3):244-50. (PMID: 26261776)
Curr Neurol Neurosci Rep. 2022 Aug;22(8):491-498. (PMID: 35727462)
PLoS Pathog. 2017 Dec 7;13(12):e1006657. (PMID: 29216334)
Am J Trop Med Hyg. 2010 Mar;82(3):368-70. (PMID: 20207857)
J Clin Microbiol. 2015 Nov;53(11):3663-6. (PMID: 26354819)
Clin Infect Dis. 2009 Mar 15;48 Suppl 3:S203-30. (PMID: 19220144)
Heliyon. 2022 Nov 03;8(11):e11356. (PMID: 36411909)
J Adv Res. 2018 Jul 18;15:111-116. (PMID: 30581619)
J Clin Microbiol. 2018 Jul 26;56(8):. (PMID: 29769278)
N Engl J Med. 2017 Aug 10;377(6):562-572. (PMID: 28792873)
Pediatr Blood Cancer. 2007 Feb;48(2):124-31. (PMID: 16937360)
PLoS Negl Trop Dis. 2015 Aug 14;9(8):e0003971. (PMID: 26274584)
J Med Case Rep. 2019 Dec 7;13(1):358. (PMID: 31810465)
Lancet Infect Dis. 2006 Jul;6(7):447-54. (PMID: 16790385)
Nat Commun. 2022 Jun 23;13(1):3603. (PMID: 35739103)
BMC Infect Dis. 2014 Mar 12;14:139. (PMID: 24620733)
Indian J Med Microbiol. 2019 Jan-Mar;37(1):113-115. (PMID: 31424021)
J Assoc Physicians India. 2019 Apr;67(4):38-40. (PMID: 31309794)
J Trop Pediatr. 2021 Jan 29;67(1):. (PMID: 33547467)
Front Med (Lausanne). 2022 Apr 27;9:831045. (PMID: 35573006)
Blood. 2020 Apr 16;135(16):1332-1343. (PMID: 32107531)
Trop Med Infect Dis. 2018 Feb 14;3(1):. (PMID: 30274417)
Emerg Infect Dis. 2016 Aug;22(8):1460-3. (PMID: 27433834)
PLoS Negl Trop Dis. 2017 Feb 27;11(2):e0005397. (PMID: 28241043)
Korean J Intern Med. 2003 Dec;18(4):248-50. (PMID: 14717236)
Nat Rev Genet. 2019 Jun;20(6):341-355. (PMID: 30918369)
Pathogens. 2023 Jan 12;12(1):. (PMID: 36678476)
PLoS Negl Trop Dis. 2017 Nov 3;11(11):e0006062. (PMID: 29099844)
Trop Doct. 2011 Apr;41(2):111-2. (PMID: 21149571)
Clin Exp Nephrol. 2013 Oct;17(5):725-729. (PMID: 23292176)
Zhonghua Liu Xing Bing Xue Za Zhi. 2013 Sep;34(9):946-7. (PMID: 24380098)
Trans R Soc Trop Med Hyg. 2017 Feb 1;111(2):43-54. (PMID: 28449088)
PLoS Negl Trop Dis. 2017 Sep 25;11(9):e0005838. (PMID: 28945755) - Contributed Indexing: Keywords: Orientia tsutsugamushi; hemophagocytic lymphohistiocytosis; metagenomics next-generation sequencing; scrub typhus; sepsis
- Accession Number: N12000U13O (Doxycycline)
- Publication Date: Date Created: 20240524 Date Completed: 20240524 Latest Revision: 20240525
- Publication Date: 20240525
- Accession Number: PMC11111966
- Accession Number: 10.3389/fpubh.2024.1321123
- Accession Number: 38784570
- Source:
Contact CCPL
Copyright 2022 Charleston County Public Library Powered By EBSCO Stacks 3.3.0 [350.3] | Staff Login
No Comments.