Fabrication of atelocollagen-coated bioabsorbable suture and the evaluation of its regenerative efficacy in Achilles tendon healing using a rat experimental model.

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  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE
    • Publication Information:
      Publication: Amsterdam : Elsevier
      Original Publication: Guildford, Eng., IPC Science and Technology Press.
    • Subject Terms:
      Achilles Tendon*/surgery ; Achilles Tendon*/drug effects ; Achilles Tendon*/injuries ; Wound Healing*/drug effects ; Sutures* ; Collagen*/chemistry; Animals ; Rats ; Male ; Polylactic Acid-Polyglycolic Acid Copolymer/chemistry ; Absorbable Implants ; Coated Materials, Biocompatible/chemistry ; Coated Materials, Biocompatible/pharmacology ; Rats, Sprague-Dawley ; Disease Models, Animal ; Regeneration/drug effects ; Tendon Injuries/surgery
    • Abstract:
      Recently, the incidence of Achilles tendon ruptures (ATRs) has become more common, and repair surgery using a bioabsorbable suture is generally preferred, particularly in the case of healthy patients. Sutures composed of poly(lactic-co-glycolic acid) (PLGA) are commonly used in ATR surgeries. Nevertheless, owing to the inherent limitations of PLGA, novel bioabsorbable sutures that can accelerate Achilles tendon healing are sought. Recently, several studies have demonstrated the beneficial effects of atelocollagen on tendon healing. In this study, poly(3,4-dihydroxy-L-phenylalanine) (pDOPA), a hydrophilic biomimetic material, was used to modify the hydrophobic surface of a PLGA suture (Vicryl, VC) for the stable coating of atelocollagen on its surface. The main objective was to fabricate an atelocollagen-coated VC suture and evaluate its performance in the healing of Achilles tendon using a rat model of open repair for ATR. Structural analyses of the surface-modified suture indicated that the collagen was successfully coated on the VC/pDOPA suture. Postoperative in vivo biomechanical analysis, histological evaluation, ultrastructural/morphological analyses, and western blotting confirmed that the tendons in the VC/pDOPA/Col group exhibit superior healing than those in the VC and VC/pDOPA groups after 1 and 6 weeks following the surgery. The this study suggests that atelocollagen-coated PLGA/pDOPA sutures are preferable for future medical applications, especially in the repair of ATR.
      Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
      (Copyright © 2024 Elsevier B.V. All rights reserved.)
    • Contributed Indexing:
      Keywords: Achilles tendon rupture; Coating; Collagen; PLGA suture; pDOPA
    • Accession Number:
      0 (atelocollagen)
      9007-34-5 (Collagen)
      1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
      0 (Coated Materials, Biocompatible)
    • Publication Date:
      Date Created: 20240523 Date Completed: 20240619 Latest Revision: 20240619
    • Publication Date:
      20240619
    • Accession Number:
      10.1016/j.ijbiomac.2024.132564
    • Accession Number:
      38782324