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Vertebrates on a Chip: Noninvasive Electrical and Optical Mapping of Whole Brain Activity Associated with Pharmacological Treatments.
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- Author(s): Liu Z;Liu Z; Luo X; Luo X; Yan-Do R; Yan-Do R; Yan-Do R; Wang Y; Wang Y; Xie X; Xie X; Li Z; Li Z; Cheng SH; Cheng SH; Shi P; Shi P; Shi P; Shi P; Shi P
- Source:
ACS chemical neuroscience [ACS Chem Neurosci] 2024 Jun 05; Vol. 15 (11), pp. 2121-2131. Date of Electronic Publication: 2024 May 22.- Publication Type:
Journal Article; Research Support, Non-U.S. Gov't- Language:
English - Source:
- Additional Information
- Source: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101525337 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1948-7193 (Electronic) Linking ISSN: 19487193 NLM ISO Abbreviation: ACS Chem Neurosci Subsets: MEDLINE
- Publication Information: Original Publication: Washington, D.C. : American Chemical Society
- Subject Terms:
- Abstract: Mapping brain activities is necessary for understanding brain physiology and discovering new treatments for neurological disorders. Such efforts have greatly benefited from the advancement in technologies for analyzing neural activity with improving temporal or spatial resolution. Here, we constructed a multielectrode array based brain activity mapping (BAM) system capable of stabilizing and orienting zebrafish larvae for recording electroencephalogram (EEG) like local field potential (LFP) signals and brain-wide calcium dynamics in awake zebrafish. Particularly, we designed a zebrafish trap chip that integrates with an eight-by-eight surface electrode array, so that brain electrophysiology can be noninvasively recorded in an agarose-free and anesthetic-free format with a high temporal resolution of 40 μs, matching the capability typically achieved by invasive LFP recording. Benefiting from the specially designed hybrid system, we can also conduct calcium imaging directly on immobilized awake larval zebrafish, which further supplies us with high spatial resolution brain-wide activity data. All of these innovations reconcile the limitations of sole LFP recording or calcium imaging, emphasizing a synergy of combining electrical and optical modalities within one unified device for activity mapping across a whole vertebrate brain with both improved spatial and temporal resolutions. The compatibility with in vivo drug treatment further makes it suitable for pharmacology studies based on multimodal measurement of brain-wide physiology.
- Contributed Indexing: Keywords: Noninvasive EEG; brain activity mapping; drug screening; electrophysiology; larval zebrafish; multielectrode array
- Accession Number: SY7Q814VUP (Calcium)
- Publication Date: Date Created: 20240522 Date Completed: 20240605 Latest Revision: 20240613
- Publication Date: 20240614
- Accession Number: 10.1021/acschemneuro.4c00158
- Accession Number: 38775291
- Source:
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