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Effect of intracerebroventricular (ICV) injection of adrenomedullin and its interaction with NPY and CCK pathways on food intake regulation in neonatal layer-type chicks.
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- Author(s): Zahed MS;Zahed MS; Alimohammadi S; Alimohammadi S; Hassanpour S; Hassanpour S
- Source:
Poultry science [Poult Sci] 2024 Jul; Vol. 103 (7), pp. 103819. Date of Electronic Publication: 2024 May 06.- Publication Type:
Journal Article- Language:
English - Source:
- Additional Information
- Source: Publisher: Elsevier Country of Publication: England NLM ID: 0401150 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-3171 (Electronic) Linking ISSN: 00325791 NLM ISO Abbreviation: Poult Sci Subsets: MEDLINE
- Publication Information: Publication: 2020- : [Cambridge, UK] : Elsevier
Original Publication: Champaign Il : Poultry Science Association - Subject Terms: Adrenomedullin*/administration & dosage ; Adrenomedullin*/pharmacology ; Chickens*/physiology; Animals ; Injections, Intraventricular/veterinary ; Neuropeptide Y/administration & dosage ; Neuropeptide Y/pharmacology ; Neuropeptide Y/metabolism ; Eating/drug effects ; Female ; Avian Proteins/metabolism ; Appetite Regulation/drug effects ; Appetite Regulation/physiology ; Male ; Receptors, Cholecystokinin ; Cholecystokinin/administration & dosage ; Cholecystokinin/pharmacology
- Abstract: Adrenomedullin has various physiological roles including appetite regulation. The objective of present study was to determine the effects of ICV injection of adrenomedullin and its interaction with NPY and CCK receptors on food intake regulation. In experiment 1, chickens received ICV injection of saline and adrenomedullin (1, 2, and 3 nmol). In experiment 2, birds injected with saline, B5063 (NPY
1 receptor antagonist, 1.25 µg), adrenomedullin (3 nmol) and co-injection of B5063+adrenomedullin. Experiments 3 to 5 were similar to experiment 2 and only SF22 (NPY2 receptor antagonist, 1.25 µg), SML0891 (NPY5 receptor antagonist, 1.25 µg) and CCK4 (1 nmol) were injected instead of B5063. In experiment 6, ICV injection of saline and CCK8s (0.125, 0.25, and 0.5 nmol) were done. In experiment 7, chickens injected with saline, CCK8s (0.125 nmol), adrenomedullin (3 nmol) and co-injection of CCK8s +adrenomedullin. After ICV injection, birds were returned to their individual cages immediately and cumulative food intake was measured at 30, 60, and 120 min after injection. Adrenomedullin (2 and 3 nmol) decreased food intake compared to control group (P < 0.05). Coinjection of B5063+adrenomedullin amplified hypophagic effect of adrenomedullin (P < 0.05). The ICV injection of the CCK8s (0.25 and 0.5 nmol) reduced food intake (P < 0.05). Co-injection of the CCK8s +adrenomedullin significantly potentiated adrenomedullin-induced hypophagia (P < 0.05). Administration of the SF22, SML0891 and CCK4 had no effect on the anorexigenic response evoked by adrenomedullin (P > 0.05). These results suggested that the hypophagic effect of the adrenomedullin is mediated by NPY1 and CCK8s receptors. However, our novel results should form the basis for future experiments.
(Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.) - Contributed Indexing: Keywords: CCK; NPY; adrenomedullin; chicken; food intake
- Accession Number: 148498-78-6 (Adrenomedullin)
0 (Neuropeptide Y)
0 (Avian Proteins)
0 (Receptors, Cholecystokinin)
9011-97-6 (Cholecystokinin) - Publication Date: Date Created: 20240521 Date Completed: 20240622 Latest Revision: 20240711
- Publication Date: 20240711
- Accession Number: PMC11131059
- Accession Number: 10.1016/j.psj.2024.103819
- Accession Number: 38772088
- Source:
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