Contact sensitization and self-reported eczema in Swedish painters with occupational exposure to isothiazolinones.

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  • Additional Information
    • Source:
      Publisher: Wiley Country of Publication: England NLM ID: 7604950 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0536 (Electronic) Linking ISSN: 01051873 NLM ISO Abbreviation: Contact Dermatitis Subsets: MEDLINE
    • Publication Information:
      Publication: <2005-> : Oxford : Wiley
      Original Publication: Copenhagen, Munksgaard.
    • Subject Terms:
      Thiazoles*/adverse effects ; Dermatitis, Allergic Contact*/etiology ; Dermatitis, Allergic Contact*/diagnosis ; Dermatitis, Occupational*/etiology ; Dermatitis, Occupational*/diagnosis ; Dermatitis, Occupational*/epidemiology ; Patch Tests* ; Preservatives, Pharmaceutical*/adverse effects ; Occupational Exposure*/adverse effects ; Eczema*/chemically induced ; Eczema*/epidemiology ; Paint*/adverse effects; Humans ; Sweden/epidemiology ; Male ; Adult ; Middle Aged ; Female ; Self Report ; Surveys and Questionnaires
    • Abstract:
      Background: Due to an increasing occupational usage of isothiazolinone (IT)-containing preservatives, and their potential to cause skin sensitization and allergic contact dermatitis, that is, chronic disease, there is a need for more knowledge on how highly exposed workers are affected.
      Objectives: The overall objective was to explore dermatological symptoms of potentially long-lasting or chronic character in Swedish painters.
      Methods: Building painters from western and southern Sweden were initially invited to perform a questionnaire on occurrence of skin symptoms. Participants with affirmative responses, and the right inclusion criteria, were further invited to patch testing with four different ITs: benzisothiazolinone (BIT), methylisothiazolinone, methylchloroisothiazolinone and octylisothiazolinone.
      Results: There was a tendency towards higher occurrence of positive patch test reactions among the painters compared with occupationally unexposed registry patients; however, not statistically significant differences. BIT was the substance most frequently causing positive test results in both groups. The occurrence of adult-onset eczema was higher in painters than in the control group of electricians, and just shy of statistical significance concerning any of several skin locations (face/legs/arms/hands).
      Conclusion: Building painters present with positive patch test reactions to common paint preservatives (ITs), and they report adult-onset eczema more often than do less occupationally exposed groups.
      (© 2024 The Authors. Contact Dermatitis published by John Wiley & Sons Ltd.)
    • References:
      Silva V, Silva C, Soares P, Garrido EM, Borges F, Garrido J. Isothiazolinone biocides: chemistry, biological, and toxicity profiles. Molecules. 2020;25(4):991. doi:10.3390/molecules25040991.
      Diepgen TL. Occupational skin diseases. J Dtsch Dermatol Ges. 2012;10(5):297‐313; quiz 314–315. doi:10.1111/j.1610‐0387.2012.07890.x.
      Schwensen JF, Lundov MD, Bossi R, et al. Methylisothiazolinone and benzisothiazolinone are widely used in paint: a multicentre study of paints from five European countries. Contact Dermatitis. 2015;72(3):127‐138. doi:10.1111/cod.12322.
      Thomsen AV, Schwensen JF, Bossi R, et al. Isothiazolinones are still widely used in paints purchased in five European countries: a follow‐up study. Contact Dermatitis. 2018;78(4):246‐253. doi:10.1111/cod.12937.
      Goodier MC, Siegel PD, Zang LY, Warshaw EM. Isothiazolinone in residential interior wall paint: a high‐performance liquid chromatographic‐mass spectrometry analysis. Dermatitis. 2018;29(6):332‐338. doi:10.1097/DER.0000000000000410.
      Yazar K, Johnsson S, Lind ML, Boman A, Liden C. Preservatives and fragrances in selected consumer‐available cosmetics and detergents. Contact Dermatitis. 2011;64(5):265‐272. doi:10.1111/j.1600‐0536.2010.01828.x.
      Amsler E, Aerts O, Raison‐Peyron N, et al. Airborne allergic contact dermatitis caused by isothiazolinones in water‐based paints: a retrospective study of 44 cases. Contact Dermatitis. 2017;77(3):163‐170. doi:10.1111/cod.12795.
      Wright AM, Cahill JL. Airborne exposure to methylisothiazolinone in paint causing allergic contact dermatitis: an Australian perspective. Australas J Dermatol. 2016;57(4):294‐295. doi:10.1111/ajd.12384.
      Herman A, Aerts O, de Montjoye L, Tromme I, Goossens A, Baeck M. Isothiazolinone derivatives and allergic contact dermatitis: a review and update. J Eur Acad Dermatol Venereol. 2019;33(2):267‐276. doi:10.1111/jdv.15267.
      DeKoven JG, Warshaw EM, Belsito DV, et al. North American contact dermatitis group patch test results 2013‐2014. Dermatitis. 2017;28(1):33‐46. doi:10.1097/DER.0000000000000225.
      Mose AP, Lundov MD, Zachariae C, et al. Occupational contact dermatitis in painters: an analysis of patch test data from the Danish Contact Dermatitis Group. Contact Dermatitis. 2012;67(5):293‐297. doi:10.1111/j.1600‐0536.2012.02074.x.
      Schwensen JF, Friis UF, Menne T, Flyvholm MA, Johansen JD. Contact allergy to preservatives in patients with occupational contact dermatitis and exposure analysis of preservatives in registered chemical products for occupational use. Int Arch Occup Environ Health. 2017;90(4):319‐333. doi:10.1007/s00420‐017‐1203‐5.
      Målareförbundet S. Verksamhetsberättelse 2022. https://www.malarna.nu/SysSiteAssets/kongress-2023/verksamhetsberattelse-2022-malarna.pdf.
      Alinaghi F, Bennike NH, Egeberg A, Thyssen JP, Johansen JD. Prevalence of contact allergy in the general population: a systematic review and meta‐analysis. Contact Dermatitis. 2019;80(2):77‐85. doi:10.1111/cod.13119.
      Susitaival P, Flyvholm MA, Meding B, et al. Nordic occupational skin questionnaire (NOSQ‐2002): a new tool for surveying occupational skin diseases and exposure. Contact Dermatitis. 2003;49(2):70‐76. doi:10.1111/j.0105‐1873.2003.00159.x.
      Johansen JD, Bonefeld CM, Schwensen JFB, Thyssen JP, Uter W. Novel insights into contact dermatitis. J Allergy Clin Immunol. 2022;149(4):1162‐1171. doi:10.1016/j.jaci.2022.02.002.
      Agresti A. Categorical Data Analysis. Wiley Series in Probability and Statistics. Vol 792. 3rd ed. Wiley‐Interscience; 2013. doi:10.1002/0471249688.
      Ljubojevic Hadzavdic S, Pustisek N, Zuzul K, Svigir A. Contact allergy: an update. G Ital Dermatol Venereol. 2018;153(3):419‐428. doi:10.23736/S0392‐0488.17.05844‐8.
      Novak‐Bilic G, Vucic M, Japundzic I, Mestrovic‐Stefekov J, Stanic‐Duktaj S, Lugovic‐Mihic L. Irritant and allergic contact dermatitis—skin lesion characteristics. Acta Clin Croat. 2018;57(4):713‐720. doi:10.20471/acc.2018.57.04.13.
      Brites GS, Ferreira I, Sebastiao AI, et al. Allergic contact dermatitis: from pathophysiology to development of new preventive strategies. Pharmacol Res. 2020;162:105282. doi:10.1016/j.phrs.2020.105282.
      Schubert S, Bauer A, Hillen U, et al. Occupational contact dermatitis in painters and varnishers: data from the information network of departments of dermatology (IVDK), 2000 to 2019. Contact Dermatitis. 2021;85(5):494‐502. doi:10.1111/cod.13935.
      Schwensen JF, Menné Bonefeld C, Zachariae C, et al. Cross‐reactivity between methylisothiazolinone, octylisothiazolinone and benzisothiazolinone using a modified local lymph node assay. Br J Dermatol. 2017;176(1):176‐183. doi:10.1111/bjd.14825.
      Mose AP, Frost S, Ohlund U, Andersen KE. Allergic contact dermatitis from octylisothiazolinone. Contact Dermatitis. 2013;69(1):49‐52. doi:10.1111/cod.12068.
      Basketter DA, Rodford R, Kimber I, Smith I, Wahlberg JE. Skin sensitization risk assessment: a comparative evaluation of 3 isothiazolinone biocides. Contact Dermatitis. 1999;40(3):150‐154. doi:10.1111/j.1600‐0536.1999.tb06013.x.
      Kim H, Park J, Lee H, et al. Potency classification of isothiazolinone compounds based on defined approaches of skin sensitization in OECD GL 497. Environ Anal Health Toxicol. 2023;38(4):e2023026‐0. doi:10.5620/eaht.2023026.
      Fischer T, Bohlin S, Edling C, Rystedt I, Wieslander G. Skin disease and contact sensitivity in house painters using water‐based paints, glues and putties. Contact Dermatitis. 1995;32(1):39‐45. doi:10.1111/j.1600‐0536.1995.tb00839.x.
      Wieslander G, Norback D, Edling C. Occupational exposure to water based paint and symptoms from the skin and eyes. Occup Environ Med. 1994;51(3):181‐186. doi:10.1136/oem.51.3.181.
      Kaukiainen A, Riala R, Martikainen R, Estlander T, Susitaival P, Aalto‐Korte K. Chemical exposure and symptoms of hand dermatitis in construction painters. Contact Dermatitis. 2005;53(1):14‐21. doi:10.1111/j.0105‐1873.2005.00618.x.
      Saulyte J, Regueira C, Montes‐Martinez A, Khudyakov P, Takkouche B. Active or passive exposure to tobacco smoking and allergic rhinitis, allergic dermatitis, and food allergy in adults and children: a systematic review and meta‐analysis. PLoS Med. 2014;11(3):e1001611. doi:10.1371/journal.pmed.1001611.
    • Grant Information:
      AFA Försäkring
    • Contributed Indexing:
      Keywords: allergic contact dermatitis; eczema; isothiazolinone; painter; patch test; sensitization
    • Accession Number:
      0 (Thiazoles)
      229D0E1QFA (2-methyl-4-isothiazolin-3-one)
      DEL7T5QRPN (5-chloro-2-methyl-4-isothiazolin-3-one)
      0 (Preservatives, Pharmaceutical)
      HRA0F1A4R3 (1,2-benzisothiazoline-3-one)
      4LFS24GD0V (2-n-octyl-4-isothiazolin-3-one)
    • Publication Date:
      Date Created: 20240521 Date Completed: 20240711 Latest Revision: 20240711
    • Publication Date:
      20240711
    • Accession Number:
      10.1111/cod.14572
    • Accession Number:
      38769738