Linking Aging to Cancer: The Role of Chromatin Biology.

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  • Additional Information
    • Source:
      Publisher: published on behalf of the Gerontological Society of America by Oxford University Press Country of Publication: United States NLM ID: 9502837 Publication Model: Print Cited Medium: Internet ISSN: 1758-535X (Electronic) Linking ISSN: 10795006 NLM ISO Abbreviation: J Gerontol A Biol Sci Med Sci Subsets: MEDLINE
    • Publication Information:
      Publication: Washington, DC : published on behalf of the Gerontological Society of America by Oxford University Press
      Original Publication: Washington, DC : Gerontological Society of America, c1995-
    • Subject Terms:
      Aging*/genetics ; Aging*/physiology ; Chromatin*/genetics ; Chromatin*/metabolism ; Neoplasms*/genetics ; Epigenesis, Genetic*; Humans ; Cellular Senescence/genetics ; Cellular Senescence/physiology ; Genomic Instability/genetics ; Chromatin Assembly and Disassembly/genetics ; DNA Methylation ; Histones/metabolism ; Animals ; Protein Processing, Post-Translational
    • Abstract:
      Epigenetic changes have been established to be a hallmark of aging, which implies that aging science requires collaborating with the field of chromatin biology. DNA methylation patterns, changes in relative abundance of histone post-translational modifications, and chromatin remodeling are the central players in modifying chromatin structure. Aging is commonly associated with an overall increase in chromatin instability, loss of homeostasis, and decondensation. However, numerous publications have highlighted that the link between aging and chromatin changes is not nearly as linear as previously expected. This complex interplay of these epigenetic elements during the lifetime of an organism likely contributes to cellular senescence, genomic instability, and disease susceptibility. Yet, the causal links between these phenomena still need to be fully unraveled. In this perspective article, we discuss potential future directions of aging chromatin biology.
      (© The Author(s) 2024. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For commercial re-use, please contact [email protected] for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact [email protected].)
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    • Grant Information:
      ZIA AG000679 United States ImNIH Intramural NIH HHS; Hevolution Foundations; Einstein Nathan Shock Institute; Merck, Relay Therapeutics, Deerfield; American Federation for Aging Research; Einstein-Mount Sinai Diabetes Center; ZIA AG000679 United States AG NIA NIH HHS; 1SF2622N Research Foundation Flanders-
    • Contributed Indexing:
      Keywords: Aging; Cancer; Chromatin; Histone modifications
    • Accession Number:
      0 (Chromatin)
      0 (Histones)
    • Publication Date:
      Date Created: 20240518 Date Completed: 20240613 Latest Revision: 20240617
    • Publication Date:
      20240617
    • Accession Number:
      PMC11170291
    • Accession Number:
      10.1093/gerona/glae133
    • Accession Number:
      38761362