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Linking Aging to Cancer: The Role of Chromatin Biology.
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- Author(s): Corveleyn L;Corveleyn L; Sen P; Sen P; Adams P; Adams P; Sidoli S; Sidoli S
- Source:
The journals of gerontology. Series A, Biological sciences and medical sciences [J Gerontol A Biol Sci Med Sci] 2024 Jul 01; Vol. 79 (7).- Publication Type:
Journal Article; Review- Language:
English - Source:
- Additional Information
- Source: Publisher: published on behalf of the Gerontological Society of America by Oxford University Press Country of Publication: United States NLM ID: 9502837 Publication Model: Print Cited Medium: Internet ISSN: 1758-535X (Electronic) Linking ISSN: 10795006 NLM ISO Abbreviation: J Gerontol A Biol Sci Med Sci Subsets: MEDLINE
- Publication Information: Publication: Washington, DC : published on behalf of the Gerontological Society of America by Oxford University Press
Original Publication: Washington, DC : Gerontological Society of America, c1995- - Subject Terms: Aging*/genetics ; Aging*/physiology ; Chromatin*/genetics ; Chromatin*/metabolism ; Neoplasms*/genetics ; Epigenesis, Genetic*; Humans ; Cellular Senescence/genetics ; Cellular Senescence/physiology ; Genomic Instability/genetics ; Chromatin Assembly and Disassembly/genetics ; DNA Methylation ; Histones/metabolism ; Animals ; Protein Processing, Post-Translational
- Abstract: Epigenetic changes have been established to be a hallmark of aging, which implies that aging science requires collaborating with the field of chromatin biology. DNA methylation patterns, changes in relative abundance of histone post-translational modifications, and chromatin remodeling are the central players in modifying chromatin structure. Aging is commonly associated with an overall increase in chromatin instability, loss of homeostasis, and decondensation. However, numerous publications have highlighted that the link between aging and chromatin changes is not nearly as linear as previously expected. This complex interplay of these epigenetic elements during the lifetime of an organism likely contributes to cellular senescence, genomic instability, and disease susceptibility. Yet, the causal links between these phenomena still need to be fully unraveled. In this perspective article, we discuss potential future directions of aging chromatin biology.
(© The Author(s) 2024. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For commercial re-use, please contact [email protected] for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact [email protected].) - References: Genome Res. 2010 Apr;20(4):440-6. (PMID: 20219944)
Ibrain. 2023 May 17;9(2):205-213. (PMID: 37786548)
Cell Stem Cell. 2018 Feb 1;22(2):252-261.e4. (PMID: 29358044)
Sci Rep. 2019 Aug 19;9(1):11960. (PMID: 31427598)
Nature. 2009 Jun 11;459(7248):802-7. (PMID: 19516333)
Aging (Albany NY). 2018 Oct 11;10(10):2585-2605. (PMID: 30312172)
Aging Cell. 2015 Dec;14(6):924-32. (PMID: 25913071)
Neuron. 2015 Jul 1;87(1):77-94. (PMID: 26139371)
J Exp Biol. 2015 Jan 1;218(Pt 1):59-70. (PMID: 25568452)
Nat Aging. 2023 Apr;3(4):402-417. (PMID: 37117791)
Reprod Biol Endocrinol. 2023 Apr 20;21(1):38. (PMID: 37081483)
Cell. 2013 Jun 6;153(6):1194-217. (PMID: 23746838)
Proc Natl Acad Sci U S A. 2006 Jun 6;103(23):8703-8. (PMID: 16738054)
Mol Cell. 2023 May 18;83(10):1659-1676.e11. (PMID: 37116496)
Aging Cell. 2018 Jun;17(3):e12744. (PMID: 29504244)
FEBS Lett. 2011 Jul 7;585(13):2041-8. (PMID: 21081125)
Nat Genet. 2007 Feb;39(2):237-42. (PMID: 17211412)
Cell Stem Cell. 2023 Nov 2;30(11):1452-1471.e10. (PMID: 37832549)
Curr Opin Genet Dev. 2011 Feb;21(1):100-6. (PMID: 21087854)
Genes Dev. 2011 Nov 1;25(21):2248-53. (PMID: 22056670)
Nat Chem Biol. 2011 Jan;7(1):58-63. (PMID: 21151122)
Ann N Y Acad Sci. 2018 Apr;1418(1):69-79. (PMID: 29363785)
Int J Mol Sci. 2020 Nov 03;21(21):. (PMID: 33153221)
Genome Res. 2019 Apr;29(4):697-709. (PMID: 30858345)
Nat Aging. 2023 Apr;3(4):374-375. (PMID: 37117792)
Sci Rep. 2022 Jan 24;12(1):1256. (PMID: 35075221)
Genome Res. 2010 Apr;20(4):434-9. (PMID: 20219945)
Biomedicines. 2023 Apr 22;11(5):. (PMID: 37238909)
Am J Physiol Heart Circ Physiol. 2016 Aug 1;311(2):H347-63. (PMID: 27261364)
Nat Genet. 2007 Feb;39(2):157-8. (PMID: 17200673)
Appl Transl Genom. 2015 Feb 04;4:23-32. (PMID: 26937346)
Cell. 2018 May 31;173(6):1385-1397.e14. (PMID: 29706550)
Aging (Albany NY). 2020 Jan 28;12(2):1044-1046. (PMID: 31991401)
Nat Commun. 2019 May 9;10(1):2119. (PMID: 31073172)
Mol Cell. 2019 Feb 21;73(4):684-698.e8. (PMID: 30773298)
Cell. 2016 Aug 11;166(4):822-839. (PMID: 27518561)
Nature. 2011 Apr 14;472(7342):221-5. (PMID: 21346760)
J Am Geriatr Soc. 2004 Feb;52(2):274-7. (PMID: 14728640)
Genes Dev. 2015 Jul 1;29(13):1362-76. (PMID: 26159996)
Mol Cell. 2010 Sep 10;39(5):724-35. (PMID: 20832724)
Genes Dis. 2019 Oct 08;7(2):166-171. (PMID: 32215286)
Exp Gerontol. 1997 Jul-Oct;32(4-5):383-94. (PMID: 9315443)
Clin Epigenetics. 2015 Mar 25;7:33. (PMID: 25861393) - Grant Information: ZIA AG000679 United States ImNIH Intramural NIH HHS; Hevolution Foundations; Einstein Nathan Shock Institute; Merck, Relay Therapeutics, Deerfield; American Federation for Aging Research; Einstein-Mount Sinai Diabetes Center; ZIA AG000679 United States AG NIA NIH HHS; 1SF2622N Research Foundation Flanders-
- Contributed Indexing: Keywords: Aging; Cancer; Chromatin; Histone modifications
- Accession Number: 0 (Chromatin)
0 (Histones) - Publication Date: Date Created: 20240518 Date Completed: 20240613 Latest Revision: 20240617
- Publication Date: 20240617
- Accession Number: PMC11170291
- Accession Number: 10.1093/gerona/glae133
- Accession Number: 38761362
- Source:
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