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Multifunctional Nanofibrous Hollow Microspheres for Enhanced Periodontal Bone Regeneration.
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- Author(s): Li Q;Li Q;Li Q; Ma C; Ma C; Ma C; Ma C; Jing Y; Jing Y; Liu X; Liu X; Liu X
- Source:
Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2024 Jul; Vol. 11 (28), pp. e2402335. Date of Electronic Publication: 2024 May 17.- Publication Type:
Journal Article- Language:
English - Source:
- Additional Information
- Source: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE
- Publication Information: Original Publication: Weinheim : WILEY-VCH, [2014]-
- Subject Terms:
- Abstract: Destructive periodontitis destroys alveolar bone and eventually leads to tooth loss. While guided bone regeneration, which is based on creating a physical barrier to hinder the infiltration of epithelial and connective tissues into defect sites, has been widely used for alveolar bone regeneration, its outcomes remain variable. In this work, a multifunctional nanofibrous hollow microsphere (NFHMS) is developed for enhanced alveolar bone regeneration. The NFHMS is first prepared via combining a double emulsification and a thermally induced phase separation process. Next, E7, a short peptide with high specific affinity to bone marrow-derived stem cells (BMSCs), is conjugated onto the surface of NFHMS. After that, bone forming peptide (BFP), a short peptide derived from bone morphology protein 7 is loaded in calcium phosphate (CaP) nanoparticles, which are further encapsulated in the hollow space of the NFHMS-E7 to form NFHMS-E7-CaP/BFP. The NFHMS-E7-CaP/BFP selectively promoted the adhesion of BMSCs and expelled the adhesion of fibroblasts and epithelial cells. In addition, the BFP is sustainedly released from the NFHMS-E7-CaP/BFP to enhance the osteogenesis of BMSCs. A rat challenging fenestration defect model showed that the NFHMS-E7-CaP/BFP significantly enhanced alveolar bone tissue regeneration. This work provides a novel bioengineering approach for guided bone regeneration.
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Tissue Eng Part B Rev. 2016 Aug;22(4):284-97. (PMID: 26857241) - Grant Information: R01 DE029808 United States DE NIDCR NIH HHS; R01 DE032540 United States DE NIDCR NIH HHS; DE032540 United States DE NIDCR NIH HHS; DE029808 United States DE NIDCR NIH HHS
- Contributed Indexing: Keywords: alveolar bone regeneration; injectable; microspheres; nanofibers; periodontitis
- Accession Number: 0 (Calcium Phosphates)
97Z1WI3NDX (calcium phosphate) - Publication Date: Date Created: 20240517 Date Completed: 20240724 Latest Revision: 20240726
- Publication Date: 20240726
- Accession Number: PMC11267322
- Accession Number: 10.1002/advs.202402335
- Accession Number: 38757666
- Source:
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