Identification of a novel QTL for lean meat percentage using imputed genotypes.

Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 8605704 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2052 (Electronic) Linking ISSN: 02689146 NLM ISO Abbreviation: Anim Genet Subsets: MEDLINE

Publication: Oxford, England : Wiley-Blackwell
Original Publication: Oxford, England : Published by Blackwell Scientific Publications for the International Society for Animal Blood Group Research, c1986-

Quantitative Trait Loci* ; Polymorphism, Single Nucleotide* ; Genotype* ; Sus scrofa*/genetics; Animals ; Genome-Wide Association Study/veterinary ; Breeding ; Pork Meat

Lean meat percentage is a critical production trait in pig breeding systems with direct implications for the sustainability of the industry. In this study, we conducted a genome-wide association study for lean meat percentage using a cohort of 850 Duroc × (Landrace × Yorkshire) crossbred pigs and we identified QTL on SSC3 and SSC18. Based on the predicted effect of imputed variants and using the PigGTEx database of molecular QTL, we prioritized candidate genes and SNPs located within the QTL regions, which may be involved in the regulation of porcine leanness. Our results indicate that a nonsense mutation in ZC3HAV1L on SSC18 has a direct effect on lean meat percentage.
(© 2024 The Authors. Animal Genetics published by John Wiley & Sons Ltd on behalf of Stichting International Foundation for Animal Genetics.)

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Fødevarestyrelsens; Svineafgiftsfonden

Keywords: QTL; crossbred pigs; lean meat percentage; sustainability

Date Created: 20240516 Date Completed: 20240703 Latest Revision: 20240703

20240703

10.1111/age.13442

38752377