Farm animal exposure setting impacts hemolytic uremic syndrome risk among Shiga toxin-producing Escherichia coli cases: Minnesota, 2010-2019.

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  • Additional Information
    • Source:
      Publisher: Cambridge University Press Country of Publication: England NLM ID: 8703737 Publication Model: Electronic Cited Medium: Internet ISSN: 1469-4409 (Electronic) Linking ISSN: 09502688 NLM ISO Abbreviation: Epidemiol Infect Subsets: MEDLINE
    • Publication Information:
      Original Publication: Cambridge Eng : Cambridge University Press
    • Subject Terms:
      Shiga-Toxigenic Escherichia coli*/isolation & purification ; Hemolytic-Uremic Syndrome*/epidemiology ; Hemolytic-Uremic Syndrome*/microbiology ; Escherichia coli Infections*/epidemiology ; Escherichia coli Infections*/veterinary ; Escherichia coli Infections*/microbiology; Animals ; Minnesota/epidemiology ; Humans ; Female ; Male ; Adult ; Child, Preschool ; Child ; Middle Aged ; Adolescent ; Young Adult ; Infant ; Aged ; Farms ; Ruminants/microbiology ; Aged, 80 and over ; Risk Factors
    • Abstract:
      Shiga toxin-producing Escherichia coli (STEC) transmission occurs in ruminant contact settings and can lead to post-diarrheal hemolytic uremic syndrome (HUS). We investigated whether exposure setting (ruminant exposure from living or working on a farm, visiting a farm or animal contact venue, or both) influenced HUS development among individuals with laboratory-confirmed STEC infections using Minnesota surveillance data from 2010 to 2019. Logistic regression was performed to determine whether exposure setting was associated with HUS independent of age, gender, stx2 gene detection, and county ruminants per capita. Among confirmed STEC cases, ruminant exposure only from living or working on a farm was not significantly associated with HUS compared to cases without any ruminant exposure (OR: 1.25; 95% CI: 0.51, 3.04). However, ruminant exposure only from visiting a farm or public animal contact venue was associated with HUS (OR: 2.53; 95% CI: 1.50, 4.24). Exposure from both settings was also associated with HUS (OR: 3.71; 95% CI: 1.39, 9.90). Exposure to ruminants when visiting farms or animal contact venues is an important predictor of HUS, even among people who live or work on farms with ruminants. All people, regardless of routine ruminant exposure, should take care in settings with ruminants to avoid infection with STEC.
    • Contributed Indexing:
      Keywords: Hemolytic Uremic Syndrome; Ruminant Animal Contact; Shiga toxin-producing E. coli
    • Publication Date:
      Date Created: 20240516 Date Completed: 20240821 Latest Revision: 20240821
    • Publication Date:
      20240822
    • Accession Number:
      10.1017/S0950268824000773
    • Accession Number:
      38751232