Suppression of retinal neovascularization by intravitreal injection of cryptotanshinone.

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  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE
    • Publication Information:
      Publication: <2002- >: San Diego, CA : Elsevier
      Original Publication: New York, Academic Press.
    • Subject Terms:
      Phenanthrenes*/pharmacology ; Phenanthrenes*/administration & dosage ; Retinal Neovascularization*/drug therapy ; Retinal Neovascularization*/pathology ; Retinal Neovascularization*/metabolism ; Intravitreal Injections* ; Mice, Inbred C57BL*; Animals ; Humans ; Mice ; Angiogenesis Inhibitors/pharmacology ; Angiogenesis Inhibitors/administration & dosage ; Cell Proliferation/drug effects ; Cell Movement/drug effects ; Apoptosis/drug effects ; Endothelial Cells/drug effects ; Endothelial Cells/metabolism ; Retina/drug effects ; Retina/metabolism ; Retina/pathology
    • Abstract:
      Neovascular eye diseases, including proliferative diabetic retinopathy and retinopathy of prematurity, is a major cause of blindness. Laser ablation and intravitreal anti-VEGF injection have shown their limitations in treatment of retinal neovascularization. Identification of a new therapeutic strategies is in urgent need. Our study aims to assess the effects of Cryptotanshinone (CPT), a natural compound derived from Salvia miltiorrhiza Bunge, in retina neovascularization and explore its potential mechanism. Our study demonstrated that CPT did not cause retina tissue toxicity at the tested concentrations. Intravitreal injections of CPT reduced pathological angiogenesis and promoted physical angiogenesis in oxygen-induced retinopathy (OIR) model. CPT improve visual function in OIR mice and reduced cell apoptosis. Moreover, we also revealed that CPT diminishes the expression of inflammatory cytokines in the OIR retina. In vitro, the administration of CPT effectively inhibited endothelial cells proliferation, migration, sprouting, and tube formation induced by the stimulation of human retinal vascular endothelial cells (HRVECs) with VEGF165. Mechanistically, CPT blocking the phosphorylation of VEGFR2 and downstream targeting pathway. After all, the findings demonstrated that CPT exhibits potent anti-angiogenic and anti-inflammatory effects in OIR mice, and it has therapeutic potential for the treatment of neovascular retinal diseases.
      Competing Interests: Declaration of competing interest The authors assert that they do not have any known financial interests or personal relationships that might have influenced the work reported in this paper.
      (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
    • Contributed Indexing:
      Keywords: Angiogenesis; Cryptotanshinone; Oxygen induced retinopathy; STAT3; VEGFR2
    • Accession Number:
      5E9SXT166N (cryptotanshinone)
      0 (Phenanthrenes)
      0 (Angiogenesis Inhibitors)
    • Publication Date:
      Date Created: 20240515 Date Completed: 20240603 Latest Revision: 20241011
    • Publication Date:
      20241011
    • Accession Number:
      10.1016/j.bbrc.2024.150065
    • Accession Number:
      38749188