Breast cancer and the steadily increasing maternal age: are they colliding?

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  • Additional Information
    • Source:
      Publisher: BioMed Central Country of Publication: England NLM ID: 101088690 Publication Model: Electronic Cited Medium: Internet ISSN: 1472-6874 (Electronic) Linking ISSN: 14726874 NLM ISO Abbreviation: BMC Womens Health Subsets: MEDLINE
    • Publication Information:
      Original Publication: [London] : BioMed Central, 2001-
    • Subject Terms:
      Breast Neoplasms*/epidemiology ; Maternal Age*; Humans ; Female ; Adult ; Pregnancy ; Retrospective Studies ; United States/epidemiology ; SEER Program ; Middle Aged ; Incidence ; Young Adult ; Pregnancy Complications, Neoplastic/epidemiology
    • Abstract:
      Background: Pregnancy-related cancers are mostly breast cancers, and their incidence is likely to increase as a result of the modern trend of delaying childbearing. In particular, advanced maternal age increases breast cancer risk, and younger breast cancer patients are more likely to die and metastasize. This study compared a population with a high incidence of delayed childbearing with another population with a lower mean age at childbirth in order to determine whether breast cancer diagnosis and childbearing age overlap.
      Methods: We retrospectively analyzed multiple data sources. The Surveillance, Epidemiology, and End Results (SEER) program, the United States National Center for Health Statistics as part of the National Vital Statistics System, the United Nations Population Division, the GLOBOCAN Cancer Observatory, the CLIO-INFRA project database, the Human Fertility Database, and anonymized local data were used.
      Results: As women's age at delivery increased, the convergence between their age distribution at breast cancer diagnosis and childbearing increased. In addition, the overlap between the two age distributions increased by more than 200% as the average age at delivery increased from 27 to 35 years.
      Conclusions: As women's average childbearing age has progressively risen, pregnancy and breast cancer age distributions have significantly overlapped. This finding emphasizes the need for increased awareness and educational efforts to inform women about the potential consequences of delayed childbearing. By providing comprehensive information and support, women can make more informed decisions about their reproductive health and cancer prevention strategies.
      (© 2024. The Author(s).)
    • References:
      Am J Pathol. 2010 Mar;176(3):1241-55. (PMID: 20110414)
      BMC Pregnancy Childbirth. 2016 Nov 11;16(1):352. (PMID: 27836005)
      PLoS One. 2018 May 23;13(5):e0195731. (PMID: 29791441)
      Curr Treat Options Oncol. 2000 Aug;1(3):239-43. (PMID: 12057166)
      Breast Cancer Res. 2014 Mar 28;16(2):R31. (PMID: 24678808)
      Cancer Discov. 2017 Feb;7(2):177-187. (PMID: 27974414)
      Arch Gynecol Obstet. 2023 Oct;308(4):1127-1137. (PMID: 36068364)
      Maturitas. 2000 Feb 15;34(2):119-25. (PMID: 10714906)
      BMC Pregnancy Childbirth. 2019 Jul 23;19(1):261. (PMID: 31337350)
      J Mammary Gland Biol Neoplasia. 2009 Jun;14(2):87-98. (PMID: 19381788)
      J Appl Physiol (1985). 2011 Dec;111(6):1687-93. (PMID: 21903887)
      Surg Clin North Am. 2007 Apr;87(2):417-30, x. (PMID: 17498535)
      J Clin Med. 2023 Feb 10;12(4):. (PMID: 36835955)
      BMC Womens Health. 2020 Apr 19;20(1):74. (PMID: 32307019)
      Br J Cancer. 2004 May 4;90(9):1780-3. (PMID: 15150601)
      N Engl J Med. 1994 Jul 7;331(1):5-9. (PMID: 8202106)
      J Adolesc Health. 2007 Mar;40(3):227-31. (PMID: 17321422)
      J Natl Cancer Inst. 1989 Dec 20;81(24):1879-86. (PMID: 2593165)
      Int J Cancer. 1989 Jul 15;44(1):23-30. (PMID: 2744893)
      J Med Screen. 2014 Dec;21(4):189-93. (PMID: 25186117)
      J Clin Invest. 2014 Sep;124(9):3901-12. (PMID: 25133426)
      Int J Biochem Cell Biol. 2016 Dec;81(Pt A):223-232. (PMID: 27771439)
      Curr Oncol. 2022 Nov 26;29(12):9215-9223. (PMID: 36547135)
      Br J Cancer. 2005 Jan 17;92(1):167-75. (PMID: 15597097)
      Int J Gynaecol Obstet. 2022 Oct;159(1):43-55. (PMID: 35044694)
      Springerplus. 2015 Nov 10;4:688. (PMID: 26576331)
      Cancer Res. 2020 May 1;80(9):1790-1798. (PMID: 32075799)
      BMC Pediatr. 2020 Sep 28;20(1):453. (PMID: 32988379)
      J Immunol. 2018 Jul 15;201(2):734-746. (PMID: 29884705)
      Int J Cancer. 2000 Jul 15;87(2):295-300. (PMID: 10861490)
      Nat Rev Cancer. 2006 Apr;6(4):281-91. (PMID: 16557280)
      JCI Insight. 2017 Mar 23;2(6):e89206. (PMID: 28352652)
      Int J Cancer. 1997 Sep 26;73(1):1-9. (PMID: 9334801)
      Oncologist. 2019 Dec;24(12):e1268-e1276. (PMID: 31266853)
      Natl Vital Stat Rep. 2018 Nov;67(8):1-50. (PMID: 30707672)
      J Natl Cancer Inst. 2001 Mar 7;93(5):358-66. (PMID: 11238697)
      Lancet. 2002 Jul 20;360(9328):187-95. (PMID: 12133652)
      Int J Epidemiol. 2020 Jun 1;49(3):810-823. (PMID: 32016289)
      Breast Cancer Res. 2024 Jan 22;26(1):15. (PMID: 38254178)
      Cancer Epidemiol Biomarkers Prev. 2006 Jun;15(6):1159-69. (PMID: 16775176)
      Am J Epidemiol. 1982 Nov;116(5):737-42. (PMID: 6756128)
      Popul Dev Rev. 2011;37(2):267-306. (PMID: 22066128)
      Obstet Gynecol. 2013 Sep;122(3):608-17. (PMID: 23921869)
      Front Psychol. 2019 Dec 10;10:2767. (PMID: 31920819)
      Clin Breast Cancer. 2014 Aug;14(4):235-40. (PMID: 24703317)
      Development. 1996 Jan;122(1):181-93. (PMID: 8565829)
      BMJ Glob Health. 2022 May;7(5):. (PMID: 35504693)
      Br J Cancer. 2002 Nov 18;87(11):1234-45. (PMID: 12439712)
    • Contributed Indexing:
      Keywords: Advanced maternal age; Breast cancer; Breast cancer screening; Delayed childbearing; Young women
    • Publication Date:
      Date Created: 20240514 Date Completed: 20240515 Latest Revision: 20240518
    • Publication Date:
      20240518
    • Accession Number:
      PMC11092140
    • Accession Number:
      10.1186/s12905-024-03138-4
    • Accession Number:
      38745181