Boswellic Acid and Betulinic Acid Pre-treatments Can Prevent the Nephrotoxicity Caused by Cyclophosphamide Induction.

Publisher: Pleiades Publishing Country of Publication: United States NLM ID: 101126895 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1608-3091 (Electronic) Linking ISSN: 16076729 NLM ISO Abbreviation: Dokl Biochem Biophys Subsets: MEDLINE

Publication: New York, NY : Pleiades Publishing
Original Publication: Moscow, Russia : [Dordrecht] : International Academic Pub. Co. "Nauka/Interperiodica" ; Distributed worldwide by Kluwer Academic/Plenum Publishers, c2001-

Betulinic Acid* ; Cyclophosphamide*/toxicity ; Triterpenes*/pharmacology ; Pentacyclic Triterpenes*/pharmacology ; Kidney*/drug effects ; Kidney*/metabolism ; Kidney*/pathology ; Oxidative Stress*/drug effects; Animals ; Rats ; Male ; Rats, Wistar ; Kidney Diseases/chemically induced ; Kidney Diseases/prevention & control ; Kidney Diseases/pathology ; Kidney Diseases/metabolism ; Antioxidants/pharmacology

Cyclophosphamide (CYP) is a chemotherapeutic drug used to treat various cancers. However, its clinical use is limited due to severe organ damage, particularly to the kidneys. While several phytochemicals have been identified as potential therapeutic targets for CYP nephrotoxicity, the nephroprotective effects of boswellic acid (BOSW) and betulinic acid (BET) have not yet been investigated. Our study used 42 rats divided into six equal groups. The study included six groups: control, CYP (200 mg/kg), CYP+BOSW20 (20 mg/kg), CYP+BOSW40 (40 mg/kg), CYP+BET20 (20 mg/kg), and CYP+BET40 (40 mg/kg). The pre-treatments with BOSW and BET lasted for 14 days, while the application of cyclophosphamide was performed intraperitoneally only on the 4th day of the study. After the experimental protocol, the animals were sacrificed, and their kidney tissues were isolated. Renal function parameters, histological examination, oxidative stress, and inflammation parameters were assessed both biochemically and at the molecular level in kidney tissue. The results showed that oxidative stress and inflammatory response were increased in the kidney tissue of rats treated with CYP, leading to impaired renal histology and function parameters (p < 0.05). Oral administration of both doses of BET and especially high doses of BOSW improved biochemical, oxidative, and inflammatory parameters significantly (p < 0.05). Histological studies also showed the restoration of normal kidney tissue architecture. BOSW and BET have promising biological activity against CYP-induced nephrotoxicity by attenuating inflammation and oxidative stress and enhancing antioxidant status.
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Keywords: betulinic acid; boswellic acid; cyclophosphamide; inflammation; nephrotoxicity; oxidative stress

4G6A18707N (Betulinic Acid)
8N3DW7272P (Cyclophosphamide)
0 (Triterpenes)
0 (Pentacyclic Triterpenes)
631-69-6 (boswellic acid)
0 (Antioxidants)

Date Created: 20240514 Date Completed: 20240722 Latest Revision: 20240722

20240722

10.1134/S1607672924600234

38744737