Meiotic aneuploidy: its origins and induction following chemical treatment in Sordaria brevicollis.

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  • Author(s): Bond DJ; McMillan L
  • Source:
    Environmental health perspectives [Environ Health Perspect] 1979 Aug; Vol. 31, pp. 67-74.
  • Publication Type:
    Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: National Institute of Environmental Health Sciences Country of Publication: United States NLM ID: 0330411 Publication Model: Print Cited Medium: Print ISSN: 0091-6765 (Print) Linking ISSN: 00916765 NLM ISO Abbreviation: Environ Health Perspect Subsets: MEDLINE
    • Publication Information:
      Original Publication: Research Triangle Park, N. C. National Institute of Environmental Health Sciences.
    • Subject Terms:
      Aneuploidy*; Meiosis/*drug effects; Ascomycota/genetics ; Genetic Techniques ; Mutagens ; Mutation ; Spores, Fungal ; Trifluralin/pharmacology ; p-Fluorophenylalanine/pharmacology
    • Abstract:
      A system suitable for the detection of meiotic aneuploidy is described in which various different origins of the aneuploidy can be distinguished. Aneuploid meiotic products are detected as black disomic spores held in asci containing all the products of a single meiosis. Aneuploidy may result from nondisjunction or from a meiosis in which an extra replica of one of the chromosomes has been generated in some other way, e.g., extra replication. By using this system it has been shown that pFPA treatment increase aneuploidy, primarily through an effect on nondisjunction. Preliminary results with trifluralin have indicated that this compound, too, may increase aneuploidy. There is a good possibility that the system can be further developed to permit a more rapid screening using a random plating method; this will allow a more efficient two-part analysis of the effects of compounds under test.
    • References:
      Mutat Res. 1974 Jun;26(3):159-70. (PMID: 4604824)
      Hereditas. 1969;61(1):231-54. (PMID: 5400474)
    • Accession Number:
      0 (Mutagens)
      60-17-3 (p-Fluorophenylalanine)
      C8BX46QL7K (Trifluralin)
    • Publication Date:
      Date Created: 19790801 Date Completed: 19800119 Latest Revision: 20181113
    • Publication Date:
      20231215
    • Accession Number:
      PMC1637658
    • Accession Number:
      10.1289/ehp.793167
    • Accession Number:
      387400