Experimental Approaches to Scar Modeling through Mechanical Skin Damage and Chemical Burn in Sprague Dawley Rats.

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  • Additional Information
    • Source:
      Publisher: Springer Country of Publication: United States NLM ID: 0372557 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-8221 (Electronic) Linking ISSN: 00074888 NLM ISO Abbreviation: Bull Exp Biol Med Subsets: MEDLINE
    • Publication Information:
      Publication: New York : Springer
      Original Publication: New York, Consultants Bureau.
    • Subject Terms:
      Cicatrix*/pathology ; Cicatrix*/physiopathology ; Rats, Sprague-Dawley* ; Skin*/pathology ; Skin*/injuries ; Disease Models, Animal* ; Burns, Chemical*/pathology; Animals ; Rats ; Male ; Wound Healing/physiology
    • Abstract:
      Creating of a scar model in laboratory animals is the most acceptable option for the preclinical search of scar treatment. However, due to high skin regeneration rate in laboratory rodents, creating an optimal animal model of scar formation is a challenge. Here we describe five methods for modeling a scar tissue in rats that we have tested. These methods allowed achieving different histopathological features and different stages of skin scar formation.
      (© 2024. Springer Science+Business Media, LLC, part of Springer Nature.)
    • References:
      Parnell LKS, Volk SW. The Evolution of Animal Models in Wound Healing Research: 1993-2017. Adv. Wound Care (New Rochelle). 2019;8(12):692-702. doi: https://doi.org/10.1089/wound.2019.1098. (PMID: 10.1089/wound.2019.109831827981)
      Urciuolo F, Passariello R, Imparato G, Casale C, Netti PA. Bioengineered wound healing skin models: the role of immune response and endogenous ECM to fully replicate the dynamic of scar tissue formation in vitro. Bioengineering (Basel). 2022;9(6):233. doi: https://doi.org/10.3390/bioengineering9060233. (PMID: 10.3390/bioengineering9060233357354769219817)
      Rössler S, Nischwitz SP, Luze H, Holzer-Geissler JCJ, Zrim R, Kamolz LP. In Vivo Models for Hypertrophic Scars-A Systematic Review. Medicina (Kaunas). 2022;58(6):736. doi: https://doi.org/10.3390/medicina58060736. (PMID: 10.3390/medicina58060736357439999229864)
      Zhou S, Wang W, Zhou S, Zhang G, He J, Li Q. A novel model for cutaneous wound healing and scarring in the rat. Plast. Reconstr. Surg. 2019;143(2):468-477. doi: https://doi.org/10.1097/PRS.0000000000005274. (PMID: 10.1097/PRS.000000000000527430531620)
      Ji Y, Zhu P, Zhang L, Yang H. A novel rat tail disc degeneration model induced by static bending and compression. Animal Model Exp. Med. 2021;4(3):261-267. doi: https://doi.org/10.1002/ame2.12178. (PMID: 10.1002/ame2.12178345576528446698)
      Hamidi SA, Tabatabaei Naeini A, Oryan A, Tabandeh MR, Tanideh N, Nazifi S. Cutaneous wound healing after topical application of Pistacia atlantica gel formulation in rats. Turk. J. Pharm. Sci. 2017;14(1):65-74. doi: https://doi.org/10.4274/tjps.41713. (PMID: 10.4274/tjps.41713324545967227997)
      Kim M, Kim H, Kang HW. Comparative evaluations of hypertrophic scar formation in in vivo models. Lasers Surg. Med. 2018. doi: https://doi.org/10.1002/lsm.22783. (PMID: 10.1002/lsm.2278329733104)
    • Contributed Indexing:
      Keywords: animal model; rats; scar; wound healing
    • Publication Date:
      Date Created: 20240511 Date Completed: 20240517 Latest Revision: 20240517
    • Publication Date:
      20240517
    • Accession Number:
      10.1007/s10517-024-06084-1
    • Accession Number:
      38733481