Ultrasonic-Assisted Extraction of Xanthorrhizol from Curcuma xanthorrhiza Roxb. Rhizomes by Natural Deep Eutectic Solvents: Optimization, Antioxidant Activity, and Toxicity Profiles.

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  • Additional Information
    • Source:
      Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
    • Publication Information:
      Original Publication: Basel, Switzerland : MDPI, c1995-
    • Subject Terms:
      Curcuma*/chemistry ; Antioxidants*/chemistry ; Antioxidants*/pharmacology ; Antioxidants*/isolation & purification ; Rhizome*/chemistry ; Plant Extracts*/chemistry ; Plant Extracts*/pharmacology ; Phenols*/chemistry ; Phenols*/isolation & purification ; Phenols*/pharmacology; Deep Eutectic Solvents/chemistry ; Ultrasonic Waves
    • Abstract:
      Xanthorrhizol, an important marker of Curcuma xanthorrhiza , has been recognized for its different pharmacological activities. A green strategy for selective xanthorrhizol extraction is required. Herein, natural deep eutectic solvents (NADESs) based on glucose and organic acids (lactic acid, malic acid, and citric acid) were screened for the extraction of xanthorrhizol from Curcuma xanthorrhiza . Ultrasound-assisted extraction using glucose/lactic acid (1:3) (GluLA) gave the best yield of xanthorrhizol. The response surface methodology with a Box-Behnken Design was used to optimize the interacting variables of water content, solid-to-liquid (S/L) ratio, and extraction to optimize the extraction. The optimum conditions of 30% water content in GluLA, 1/15 g/mL (S/L), and a 20 min extraction time yielded selective xanthorrhizol extraction (17.62 mg/g) over curcuminoids (6.64 mg/g). This study indicates the protective effect of GluLA and GluLA extracts against oxidation-induced DNA damage, which was comparable with those obtained for ethanol extract. In addition, the stability of the xanthorrhizol extract over 90 days was revealed when stored at -20 and 4 °C. The FTIR and NMR spectra confirmed the hydrogen bond formation in GluLA. Our study reported, for the first time, the feasibility of using glucose/lactic acid (1:3, 30% water v / v ) for the sustainable extraction of xanthorrhizol.
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    • Grant Information:
      NKB-1084/UN2.RST/HKP.05.00/2023 Ministry of Education and Culture
    • Contributed Indexing:
      Keywords: DNA protection activity; NADES; NOESY; response surface methodology; scanning electron microscopy; stability; xanthorrhizol
    • Accession Number:
      0 (Antioxidants)
      0 (xanthorrhizol)
      0 (Plant Extracts)
      0 (Phenols)
      0 (Deep Eutectic Solvents)
    • Publication Date:
      Date Created: 20240511 Date Completed: 20240511 Latest Revision: 20240514
    • Publication Date:
      20240514
    • Accession Number:
      PMC11085723
    • Accession Number:
      10.3390/molecules29092093
    • Accession Number:
      38731583