Mechanical prosthetic valve thrombosis: A literature review of treatment strategies.

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  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7701802 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-6280 (Electronic) Linking ISSN: 01462806 NLM ISO Abbreviation: Curr Probl Cardiol Subsets: MEDLINE
    • Publication Information:
      Publication: [Amsterdam] : Elsevier
      Original Publication: Chicago, Year Book Medical Publishers.
    • Subject Terms:
      Heart Valve Prosthesis*/adverse effects ; Thrombosis*/etiology ; Thrombosis*/prevention & control ; Thrombolytic Therapy*/methods ; Thrombolytic Therapy*/adverse effects ; Fibrinolytic Agents*/therapeutic use ; Anticoagulants*/therapeutic use; Humans ; Risk Factors ; Heart Valve Prosthesis Implantation/adverse effects ; Heart Valve Prosthesis Implantation/methods ; Treatment Outcome
    • Abstract:
      Mechanical prosthetic valve thrombosis (MPVT) is a common complication of valvular implantations. This study compared the efficacy and safety of different treatments for MPVT. A systematic search of electronic databases identified studies evaluating surgical, anticoagulant, and thrombolytic therapies. Although several studies of different types have been conducted to evaluate the efficacy of these treatment strategies the lack of randomized controlled trials has resulted in the inability to make a definitive conclusion about the pros and cons of these treatments. Recent treatments, such as slow and ultraslow infusion of thrombolytics, showed comparable efficacy and lower complication rates than traditional methods. Inadequate anticoagulant use is a major risk factor for MPVT, highlighting the importance of prevention. Treatment selection should be individualized based on patient factors and available expertise. Overall, slow and ultraslow infusion of thrombolytics may be a promising treatment option for MPVT.
      Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
      (Copyright © 2024 Elsevier Inc. All rights reserved.)
    • Contributed Indexing:
      Keywords: Anticoagulants; Mechanical prosthetic Valvule thrombosis; Thrombolytic therapy; Valve replacement surgeries
    • Accession Number:
      0 (Fibrinolytic Agents)
      0 (Anticoagulants)
    • Publication Date:
      Date Created: 20240510 Date Completed: 20240523 Latest Revision: 20240605
    • Publication Date:
      20240605
    • Accession Number:
      10.1016/j.cpcardiol.2024.102628
    • Accession Number:
      38729276