Ferrocene-modified half-sandwich iridium(III) and ruthenium(II) propionylhydrazone complexes and anticancer application.

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  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: United States NLM ID: 7905788 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3344 (Electronic) Linking ISSN: 01620134 NLM ISO Abbreviation: J Inorg Biochem Subsets: MEDLINE
    • Publication Information:
      Original Publication: New York, Elsevier.
    • Subject Terms:
      Ferrous Compounds*/chemistry ; Ferrous Compounds*/pharmacology ; Iridium*/chemistry ; Iridium*/pharmacology ; Antineoplastic Agents*/pharmacology ; Antineoplastic Agents*/chemistry ; Antineoplastic Agents*/chemical synthesis ; Metallocenes*/chemistry ; Metallocenes*/pharmacology ; Ruthenium*/chemistry ; Coordination Complexes*/pharmacology ; Coordination Complexes*/chemistry ; Coordination Complexes*/chemical synthesis ; Hydrazones*/chemistry ; Hydrazones*/pharmacology ; Hydrazones*/chemical synthesis ; Apoptosis*/drug effects; Humans ; A549 Cells ; Reactive Oxygen Species/metabolism ; Cell Proliferation/drug effects
    • Abstract:
      Ferrocene, ruthenium(II) and iridium(III) organometallic complexes, potential substitutes for platinum-based drugs, have shown good application prospects in the field of cancer therapy. Therefore, in this paper, six ferrocene-modified half-sandwich ruthenium(II) and iridium(III) propionylhydrazone complexes were prepared, and the anticancer potential was evaluated and compared with cisplatin. These complexes showed potential in-vitro anti-proliferative activity against A549 cancer cells, especially for Ir-based complexes, and showing favorable synergistic anticancer effect. Meanwhile, these complexes showed little cytotoxicity and effective anti-migration activity. Ir3, the most active complex (ferrocene-appended iridium(III) complex), could accumulate in the intracellular mitochondria, disturb the cell cycle (S-phase), induce the accumulation of reactive oxygen species, and eventually cause the apoptosis of A549 cells. Then, the design of these complexes provides a good structural basis for the multi-active non‑platinum organometallic anticancer complexes.
      Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
      (Copyright © 2023. Published by Elsevier Inc.)
    • Contributed Indexing:
      Keywords: Anticancer; Ferrocene; Half-sandwich structure; Iridium(III) complex; Ruthenium(II) complex
    • Accession Number:
      0 (Ferrous Compounds)
      44448S9773 (Iridium)
      0 (Antineoplastic Agents)
      0 (Metallocenes)
      U96PKG90JQ (ferrocene)
      7UI0TKC3U5 (Ruthenium)
      0 (Coordination Complexes)
      0 (Hydrazones)
      0 (Reactive Oxygen Species)
    • Publication Date:
      Date Created: 20240510 Date Completed: 20240607 Latest Revision: 20240607
    • Publication Date:
      20240608
    • Accession Number:
      10.1016/j.jinorgbio.2024.112586
    • Accession Number:
      38728860