Endothelial function in healthy centenarians living in the Madonie's district (Italy).

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  • Additional Information
    • Source:
      Publisher: Elsevier Science Country of Publication: England NLM ID: 0047061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6815 (Electronic) Linking ISSN: 05315565 NLM ISO Abbreviation: Exp Gerontol Subsets: MEDLINE
    • Publication Information:
      Publication: Tarrytown Ny : Elsevier Science
      Original Publication: Oxford.
    • Subject Terms:
      Brachial Artery*/physiology ; Endothelium, Vascular*/physiology ; Carotid Intima-Media Thickness* ; Ankle Brachial Index* ; Vasodilation*/physiology; Humans ; Male ; Female ; Italy ; Aged, 80 and over ; Body Composition/physiology ; Aged ; Case-Control Studies ; Middle Aged ; Aging/physiology ; Healthy Aging/physiology
    • Abstract:
      Background: Endothelial function declines with age and plays a critical role in cardiovascular health. Therefore, investigating endothelial function in successful aging models, such as centenarians, is of interest. Flow-mediated dilation (FMD) of the brachial artery is the gold standard for measuring endothelial function in vivo in humans. Therefore, we investigated, for the first time, the FMD of the brachial artery in a group of healthy centenarians.
      Methods: Selected as part of the ABCD project (nutrition, cardiovascular wellness, and diabetes) centenarians (aged ≥100 years) living in the municipalities of Madonie (Palermo, Italy) were compared with a younger (aged <65 years) sex-matched control group from the ABCD general cohort. FMD of the brachial artery was measured in all participants using a real-time computed video analysis system for B-mode ultrasound images. Body composition (bioimpedance), carotid intima-media thickness (IMT), and ankle-brachial index (ABI) were also measured.
      Results: Eleven participants (males 36.4 %; age: 101 ± 1 years) out of 28 healthy centenarians successfully cooperated with the FMD test procedures, which require remaining with the upper limb immobile for approximately 10 min. This subgroup was compared with a control group of 76 healthy and younger individuals (males 36.8 %; aged: 41 ± 14 years; P < 0.001). Centenarians exhibited better endothelial function than the control group (FMD: 12.1 ± 4.3 vs 8.6 ± 5.3 %; P < 0.05). The carotid IMT was higher in the centenarian group than in the control group (0.89 ± 0.09 vs 0.56 ± 0.18 mm; P < 0.001), whereas the ABI was comparable between the two groups.
      Conclusions: This small group of centenarians demonstrated an unusually favorable endothelial function, which may contribute to their unique aging profile. Further research is needed to determine whether FMD is a valid prognostic marker for successful aging.
      Competing Interests: Declaration of competing interest The authors have no conflicts of interest to declare. Financial disclosure This research received no external funds.
      (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
    • Contributed Indexing:
      Keywords: Aging; Atherosclerosis; Centenarians; Endothelial function; Flow-mediated dilation
    • Publication Date:
      Date Created: 20240510 Date Completed: 20240530 Latest Revision: 20240530
    • Publication Date:
      20240531
    • Accession Number:
      10.1016/j.exger.2024.112457
    • Accession Number:
      38728795