The effect of papaverine on tendon healing and adhesion in rats following Achilles tendon repair.

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  • Author(s): Can E;Can E; Dincel YM; Karabulut D; Karabag S; Arslan YZ
  • Source:
    Joint diseases and related surgery [Jt Dis Relat Surg] 2024 Apr 26; Vol. 35 (2), pp. 368-376. Date of Electronic Publication: 2024 Apr 26.
  • Publication Type:
    Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Turkish Joint Diseases Foundation Country of Publication: Turkey NLM ID: 101764223 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2687-4792 (Electronic) Linking ISSN: 26874792 NLM ISO Abbreviation: Jt Dis Relat Surg Subsets: MEDLINE
    • Publication Information:
      Original Publication: Ankara, Turkey : Turkish Joint Diseases Foundation, [2020]-
    • Subject Terms:
      Achilles Tendon*/injuries ; Achilles Tendon*/drug effects ; Achilles Tendon*/pathology ; Achilles Tendon*/surgery ; Papaverine*/pharmacology ; Papaverine*/administration & dosage ; Papaverine*/therapeutic use ; Rats, Sprague-Dawley* ; Wound Healing*/drug effects ; Tendon Injuries*/drug therapy ; Tendon Injuries*/pathology ; Tendon Injuries*/surgery; Animals ; Male ; Tissue Adhesions/drug therapy ; Tissue Adhesions/pathology ; Rats ; Tensile Strength/drug effects ; Injections, Intraperitoneal ; Biomechanical Phenomena/drug effects ; Disease Models, Animal
    • Abstract:
      Objectives: The study aimed to examine the histopathological and biomechanical effects of papaverine administered intraperitoneally and locally on Achilles tendon healing in a rat model.
      Materials and Methods: Forty-eight adult male Sprague-Dawley rats (range, 300 to 400 g) were used in this study conducted between October and November 2022. The rats were divided into three groups, with each group further subdivided into two for sacrifice on either the 15 th (early period) or 30 th (late period) day after surgery. The first (control) group received no treatment following Achilles tendon repair, while papaverine was intraperitoneally administered every other day for 10 days in the second group and locally in the third group after surgery. On the 15 th and 30 th days, the rats were sacrificed, and their Achilles tendons were subjected to biomechanical testing and histopathological evaluation.
      Results: Histopathologically, there were no significant differences among the groups on the 15 th day. However, on the 30 th day, the locally applied papaverine group exhibited superior histopathological outcomes compared to the control group (p<0.05). Concerning the highest tensile strength values before rupture, the biomechanical assessment showed that the group receiving local papaverine treatment in the early period and both the group with systemic papaverine treatment and the one with local papaverine treatment in the late period displayed a statistically significant advantage compared to the control group (p<0.05).
      Conclusion: Locally administered papaverine has positive biomechanical effects in the early period and exhibits a positive correlation both histopathologically and biomechanically in the late period. Novel therapeutic options may be provided for patients through these findings.
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    • Accession Number:
      DAA13NKG2Q (Papaverine)
    • Publication Date:
      Date Created: 20240510 Date Completed: 20240510 Latest Revision: 20240529
    • Publication Date:
      20240529
    • Accession Number:
      PMC11128969
    • Accession Number:
      10.52312/jdrs.2024.1656
    • Accession Number:
      38727117