Age-dependent small fiber neuropathy: Mechanistic insights from animal models.

Publisher: Academic Press Country of Publication: United States NLM ID: 0370712 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2430 (Electronic) Linking ISSN: 00144886 NLM ISO Abbreviation: Exp Neurol Subsets: MEDLINE

Publication: Orlando Fl : Academic Press
Original Publication: New York.

Small Fiber Neuropathy*/pathology ; Small Fiber Neuropathy*/genetics ; Small Fiber Neuropathy*/physiopathology ; Disease Models, Animal* ; Aging*/pathology ; Aging*/physiology; Animals ; Humans

Small fiber neuropathy (SFN) is a common and debilitating disease in which the terminals of small diameter sensory axons degenerate, producing sensory loss, and in many patients neuropathic pain. While a substantial number of cases are attributable to diabetes, almost 50% are idiopathic. An underappreciated aspect of the disease is its late onset in most patients. Animal models of human genetic mutations that produce SFN also display age-dependent phenotypes suggesting that aging is an important contributor to the risk of development of the disease. In this review we define how particular sensory neurons are affected in SFN and discuss how aging may drive the disease. We also evaluate how animal models of SFN can define disease mechanisms that will provide insight into early risk detection and suggest novel therapeutic interventions.
Competing Interests: Declaration of competing interest DGT has no interests to declare. CJW is a founder of Nocion Therapeutics and on the SAB of Lundbeck Pharma.
(Copyright © 2024 Elsevier Inc. All rights reserved.)

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R35 NS105076 United States NS NINDS NIH HHS

Keywords: Aging; C-LTMRs; C-tactile afferents; Lipids; Mitochondria; Nav1.7; Peripheral neuropathy; Scn9a; Small fiber neuropathy; Sodium channels

Date Created: 20240509 Date Completed: 20240526 Latest Revision: 20240529

20240529

PMC11131160

10.1016/j.expneurol.2024.114811

38723859