Flexural pulse wave velocity in blood vessels.

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  • Additional Information
    • Source:
      Publisher: American Institute of Physics Country of Publication: United States NLM ID: 7503051 Publication Model: Print Cited Medium: Internet ISSN: 1520-8524 (Electronic) Linking ISSN: 00014966 NLM ISO Abbreviation: J Acoust Soc Am Subsets: MEDLINE
    • Publication Information:
      Publication: Melville, NY : American Institute of Physics
      Original Publication: Lancaster, Pa. [etc.] : American Institute of Physics for the Acoustical Society of America
    • Subject Terms:
      Pulse Wave Analysis*/methods ; Vascular Stiffness* ; Phantoms, Imaging* ; Models, Cardiovascular*; Humans ; Elastic Modulus ; Computer Simulation ; Arteries/physiology ; Arteries/physiopathology ; Numerical Analysis, Computer-Assisted ; Blood Flow Velocity/physiology
    • Abstract:
      Arteriosclerosis is a major risk factor for cardiovascular disease and results in arterial vessel stiffening. Velocity estimation of the pulse wave sent by the heart and propagating into the arteries is a widely accepted biomarker. This symmetrical pulse wave propagates at a speed which is related to the Young's modulus through the Moens Korteweg (MK) equation. Recently, an antisymmetric flexural wave has been observed in vivo. Unlike the symmetrical wave, it is highly dispersive. This property offers promising applications for monitoring arterial stiffness and early detection of atheromatous plaque. However, as far as it is known, no equivalent of the MK equation exists for flexural pulse waves. To bridge this gap, a beam based theory was developed, and approximate analytical solutions were reached. An experiment in soft polymer artery phantoms was built to observe the dispersion of flexural waves. A good agreement was found between the analytical expression derived from beam theory and experiments. Moreover, numerical simulations validated wave speed dependence on the elastic and geometric parameters at low frequencies. Clinical applications, such as arterial age estimation and arterial pressure measurement, are foreseen.
      (© 2024 Acoustical Society of America.)
    • Publication Date:
      Date Created: 20240508 Date Completed: 20240508 Latest Revision: 20240919
    • Publication Date:
      20240919
    • Accession Number:
      10.1121/10.0025855
    • Accession Number:
      38717204