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Sleep fragmentation exacerbates myocardial ischemia‒reperfusion injury by promoting copper overload in cardiomyocytes.
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- Author(s): Chen N;Chen N; Guo L; Guo L; Wang L; Wang L; Dai S; Dai S; Zhu X; Zhu X; Wang E; Wang E; Wang E
- Source:
Nature communications [Nat Commun] 2024 May 07; Vol. 15 (1), pp. 3834. Date of Electronic Publication: 2024 May 07.- Publication Type:
Journal Article; Research Support, Non-U.S. Gov't- Language:
English - Source:
- Additional Information
- Source: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
- Publication Information: Original Publication: [London] : Nature Pub. Group
- Subject Terms: Myocytes, Cardiac*/metabolism ; Myocytes, Cardiac*/pathology ; Copper*/metabolism ; Myocardial Reperfusion Injury*/metabolism ; Myocardial Reperfusion Injury*/pathology ; Sleep Deprivation*/physiopathology ; Sleep Deprivation*/metabolism ; Sleep Deprivation*/complications ; Apoptosis* ; Mice, Inbred C57BL*; Animals ; Male ; Mice ; Copper-Transporting ATPases/metabolism ; Copper-Transporting ATPases/genetics ; Norepinephrine/metabolism ; Norepinephrine/pharmacology ; Myocardium/metabolism ; Myocardium/pathology ; Sympathetic Nervous System/metabolism ; Disease Models, Animal
- Abstract: Sleep disorders increase the risk and mortality of heart disease, but the brain-heart interaction has not yet been fully elucidated. Cuproptosis is a copper-dependent type of cell death activated by the excessive accumulation of intracellular copper. Here, we showed that 16 weeks of sleep fragmentation (SF) resulted in elevated copper levels in the male mouse heart and exacerbated myocardial ischemia-reperfusion injury with increased myocardial cuproptosis and apoptosis. Mechanistically, we found that SF promotes sympathetic overactivity, increases the germination of myocardial sympathetic nerve terminals, and increases the level of norepinephrine in cardiac tissue, thereby inhibits VPS35 expression and leads to impaired ATP7A related copper transport and copper overload in cardiomyocytes. Copper overload further leads to exacerbated cuproptosis and apoptosis, and these effects can be rescued by excision of the sympathetic nerve or administration of copper chelating agent. Our study elucidates one of the molecular mechanisms by which sleep disorders aggravate myocardial injury and suggests possible targets for intervention.
(© 2024. The Author(s).) - References: Eur Heart J. 2021 Sep 7;42(34):3349-3357. (PMID: 33822910)
Hypertens Res. 2014 Dec;37(12):1035-6. (PMID: 25231255)
Cell Death Dis. 2022 Aug 25;13(8):733. (PMID: 36008391)
Circulation. 2023 May 9;147(19):1444-1460. (PMID: 36987924)
ACS Sens. 2022 Mar 25;7(3):775-783. (PMID: 35293731)
J Cell Sci. 2021 Nov 1;134(21):. (PMID: 34734631)
Transl Oncol. 2022 Dec;26:101502. (PMID: 36137350)
Ann N Y Acad Sci. 2006 Nov;1083:129-52. (PMID: 17148737)
Circ Res. 2022 Aug 19;131(5):456-472. (PMID: 35920168)
Theranostics. 2021 Jan 1;11(7):3052-3059. (PMID: 33537073)
J Cell Sci. 2020 Dec 24;133(24):. (PMID: 33268466)
Plant Cell. 2021 Sep 24;33(9):3042-3056. (PMID: 34125904)
Nat Protoc. 2006;1(2):824-7. (PMID: 17406313)
Exp Biol Med (Maywood). 2020 May;245(10):911-921. (PMID: 32148090)
Proc Natl Acad Sci U S A. 1993 Feb 1;90(3):1102-6. (PMID: 8430081)
Circ Res. 2014 Mar 14;114(6):1004-21. (PMID: 24625726)
Biol Trace Elem Res. 2020 Dec;198(2):636-643. (PMID: 32080790)
Cell. 2015 Sep 24;163(1):84-94. (PMID: 26406372)
Front Aging Neurosci. 2021 Feb 26;13:648115. (PMID: 33716719)
Cell Signal. 2023 Jan;101:110500. (PMID: 36270475)
Trends Endocrinol Metab. 2023 Jan;34(1):21-33. (PMID: 36435678)
Pharmacol Ther. 2015 Apr;148:66-84. (PMID: 25476109)
Toxicol In Vitro. 2019 Dec;61:104639. (PMID: 31491480)
Biomed Pharmacother. 2020 Nov;131:110791. (PMID: 33152948)
Biomolecules. 2022 Aug 23;12(9):. (PMID: 36139005)
Am J Physiol Heart Circ Physiol. 2019 Aug 1;317(2):H315-H322. (PMID: 31149842)
Am J Physiol Heart Circ Physiol. 2012 May 15;302(10):H1991-7. (PMID: 22408018)
Nature. 2019 Feb;566(7744):383-387. (PMID: 30760925)
Acta Biomater. 2021 Jul 15;129:280-292. (PMID: 34033970)
Front Cardiovasc Med. 2021 Dec 16;8:749297. (PMID: 34977176)
PLoS One. 2020 May 20;15(5):e0233357. (PMID: 32433650)
PLoS One. 2016 Jan 04;11(1):e0146022. (PMID: 26727203)
Biomed Pharmacother. 2023 Jul;163:114830. (PMID: 37150036)
Curr Opin Cell Biol. 2019 Aug;59:24-33. (PMID: 30928671)
Mol Cell Biol. 2007 Jun;27(11):4142-56. (PMID: 17371845)
Semin Cancer Biol. 2021 Nov;76:173-188. (PMID: 34058339)
Circulation. 1990 Sep;82(3 Suppl):II13-22. (PMID: 2203558)
Nat Commun. 2022 Nov 9;13(1):6762. (PMID: 36351918)
Jpn Circ J. 1978 Jun;42(6):695-9. (PMID: 713020)
J Biol Chem. 2012 Jan 20;287(4):2485-99. (PMID: 22130675)
Nanomedicine (Lond). 2022 Feb;17(5):303-324. (PMID: 35060391)
Nat Cell Biol. 2013 May;15(5):461-71. (PMID: 23563491)
J Sleep Res. 2022 Dec;31(6):e13679. (PMID: 35785454)
J Appl Physiol (1985). 2012 Jul;113(2):232-6. (PMID: 22539169)
Cardiovasc Res. 2018 Feb 1;114(2):291-299. (PMID: 29186414)
JACC Basic Transl Sci. 2022 Jul 27;7(8):800-819. (PMID: 36061338)
J Biol Chem. 2018 Mar 30;293(13):4603-4605. (PMID: 29425098)
Arterioscler Thromb Vasc Biol. 2018 Mar;38(3):529-541. (PMID: 29301787)
Circ Arrhythm Electrophysiol. 2016 Feb;9(2):e001359. (PMID: 26810594)
Exp Biol Med (Maywood). 2018 May;243(9):780-785. (PMID: 29763364)
Circ Res. 2015 Mar 13;116(6):976-90. (PMID: 25767284)
Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6848-52. (PMID: 11391006)
Metallomics. 2010 Sep;2(9):596-608. (PMID: 21072351)
Front Physiol. 2021 Sep 24;12:734009. (PMID: 34630154)
Circ Res. 2020 Jul 31;127(4):486-501. (PMID: 32349646)
Int J Mol Sci. 2022 Oct 13;23(20):. (PMID: 36293101)
Cell Death Dis. 2019 Nov 4;10(11):835. (PMID: 31685805)
Sleep Breath. 2018 May;22(2):353-359. (PMID: 28942508)
J Am Chem Soc. 2006 Jan 11;128(1):10-1. (PMID: 16390096)
J Appl Physiol (1985). 2012 Nov;113(10):1652-8. (PMID: 22797307)
Basic Res Cardiol. 1990;85 Suppl 1:9-30. (PMID: 2091611)
Scand J Work Environ Health. 2012 Mar;38(2):171-81. (PMID: 21953310)
EMBO J. 1996 Nov 15;15(22):6084-95. (PMID: 8947031)
Elife. 2017 Mar 29;6:. (PMID: 28355134)
J Am Chem Soc. 2011 Dec 14;133(49):19823-31. (PMID: 22046951)
Basic Res Cardiol. 2022 Apr 7;117(1):20. (PMID: 35389129)
Signal Transduct Target Ther. 2022 Nov 23;7(1):378. (PMID: 36414625)
Nat Rev Dis Primers. 2018 Sep 6;4(1):21. (PMID: 30190489)
Mol Biol Cell. 2015 Jan 1;26(1):91-103. (PMID: 25355947)
J Cell Sci. 2017 Aug 15;130(16):2707-2721. (PMID: 28705836)
Free Radic Biol Med. 2024 Jan;210:158-171. (PMID: 37989446)
Eur Heart J. 2011 Jun;32(12):1484-92. (PMID: 21300732)
Science. 2022 Mar 18;375(6586):1254-1261. (PMID: 35298263)
J Cell Mol Med. 2020 May;24(9):5274-5289. (PMID: 32207235)
Life Sci. 2022 Jul 1;300:120579. (PMID: 35489564)
Open Biol. 2021 Dec;11(12):210128. (PMID: 34847776)
Arq Bras Cardiol. 2016 Jan;106(1):41-8. (PMID: 26559853)
Antioxidants (Basel). 2016 Jul 27;5(3):. (PMID: 27472369)
Int J Mol Sci. 2017 Apr 20;18(4):. (PMID: 28425924)
Cardiovasc Diabetol. 2014 Jun 14;13:100. (PMID: 24927960)
Life Sci. 2019 Feb 15;219:231-237. (PMID: 30630005)
Biomed Pharmacother. 2004 Oct;58 Suppl 1:S35-9. (PMID: 15754837)
Sci Total Environ. 2023 Mar 25;866:161458. (PMID: 36621474)
Antioxidants (Basel). 2021 Apr 25;10(5):. (PMID: 33922912)
Metallomics. 2018 Jan 24;10(1):201-208. (PMID: 29302675) - Grant Information: 82170291 National Natural Science Foundation of China (National Science Foundation of China); 81800058 National Natural Science Foundation of China (National Science Foundation of China)
- Accession Number: 789U1901C5 (Copper)
EC 7.2.2.8 (Copper-Transporting ATPases)
X4W3ENH1CV (Norepinephrine)
0 (Atp7a protein, mouse) - Publication Date: Date Created: 20240507 Date Completed: 20240507 Latest Revision: 20240510
- Publication Date: 20240510
- Accession Number: PMC11076509
- Accession Number: 10.1038/s41467-024-48227-y
- Accession Number: 38714741
- Source:
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