Streptococcus suis serotype 4: a population with the potential pathogenicity in humans and pigs.

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  • Additional Information
    • Source:
      Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101594885 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2222-1751 (Electronic) Linking ISSN: 22221751 NLM ISO Abbreviation: Emerg Microbes Infect Subsets: MEDLINE
    • Publication Information:
      Publication: 2019- : [Philadelphia, PA] : Taylor & Francis
      Original Publication: New York : NPG, 2012-2018.
    • Subject Terms:
      Streptococcus suis*/pathogenicity ; Streptococcus suis*/genetics ; Streptococcus suis*/classification ; Streptococcus suis*/drug effects ; Streptococcus suis*/isolation & purification ; Streptococcal Infections*/microbiology ; Streptococcal Infections*/veterinary ; Serogroup* ; Swine Diseases*/microbiology; Animals ; Swine ; Humans ; Virulence ; Mice ; Genome, Bacterial ; Zebrafish ; Anti-Bacterial Agents/pharmacology ; Phylogeny ; Microbial Sensitivity Tests ; Virulence Factors/genetics
    • Abstract:
      Streptococcus suis is a major bacterial pathogen in pigs and an emerging zoonotic pathogen. Different S. suis serotypes exhibit diverse characteristics in population structure and pathogenicity. Surveillance data highlight the significance of S. suis serotype 4 (SS4) in swine streptococcusis, a pathotype causing human infections. However, except for a few epidemiologic studies, the information on SS4 remains limited. In this study, we investigated the population structure, pathogenicity, and antimicrobial characteristics of SS4 based on 126 isolates, including one from a patient with septicemia. We discovered significant diversities within this population, clustering into six minimum core genome (MCG) groups (1, 2, 3, 4, 7-2, and 7-3) and five lineages. Two main clonal complexes (CCs), CC17 and CC94, belong to MCG groups 1 and 3, respectively. Numerous important putative virulence-associated genes are present in these two MCG groups, and 35.00% (7/20) of pig isolates from CC17, CC94, and CC839 (also belonging to MCG group 3) were highly virulent (mortality rate ≥ 80%) in zebrafish and mice, similar to the human isolate ID36054. Cytotoxicity assays showed that the human and pig isolates of SS4 strains exhibit significant cytotoxicity to human cells. Antimicrobial susceptibility testing showed that 95.83% of strains isolated from our labs were classified as multidrug-resistant. Prophages were identified as the primary vehicle for antibiotic resistance genes. Our study demonstrates the public health threat posed by SS4, expanding the understanding of SS4 population structure and pathogenicity characteristics and providing valuable information for its surveillance and prevention.
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    • Contributed Indexing:
      Keywords: Streptococcus suis serotype 4; antimicrobial susceptibility; integrative and conjugative elements; pathogenicity; population structure; prophage
    • Publication Date:
      Date Created: 20240504 Date Completed: 20240515 Latest Revision: 20240518
    • Publication Date:
      20240518
    • Accession Number:
      PMC11097711
    • Accession Number:
      10.1080/22221751.2024.2352435
    • Accession Number:
      38703011