Association between gamma glutamyl transpeptidase to HDL-Cholesterol (GGT/HDL-C) ratio and metabolic syndrome resolution after sleeve gastrectomy.

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  • Additional Information
    • Source:
      Publisher: Sage Publications Country of Publication: England NLM ID: 101234011 Publication Model: Print Cited Medium: Internet ISSN: 1752-8984 (Electronic) Linking ISSN: 14791641 NLM ISO Abbreviation: Diab Vasc Dis Res Subsets: MEDLINE
    • Publication Information:
      Publication: 2009- : London : Sage Publications
      Original Publication: Edgbaston, Birmingham, UK : Sherborne Gibbs, c2005-
    • Subject Terms:
      Metabolic Syndrome*/blood ; Metabolic Syndrome*/diagnosis ; Biomarkers*/blood ; Cholesterol, HDL*/blood ; gamma-Glutamyltransferase*/blood ; Gastrectomy*/adverse effects; Humans ; Female ; Adult ; Male ; Retrospective Studies ; Middle Aged ; Treatment Outcome ; Time Factors ; Peru ; Predictive Value of Tests ; Obesity, Morbid/surgery ; Obesity, Morbid/blood ; Obesity, Morbid/complications ; Remission Induction ; Weight Loss ; Laparoscopy/adverse effects ; Risk Factors ; Bariatric Surgery/adverse effects
    • Abstract:
      Objective: To evaluate the association between GGT/HDL-C ratio and resolution of MetS in adults after sleeve gastrectomy (SG).
      Methods: We conducted a retrospective cohort study using secondary data from a Peruvian bariatric center. The study population consisted of adults aged 18 and above who underwent laparoscopic SG and were diagnosed with MetS prior to the surgery. The main outcome measured was MetS resolution 6 months post-surgery and the exposure variable was the GGT/HDL-C ratio.
      Results: We analyzed 137 patients with a mean age of 38.9 ± 10.9 years; 64.2% were females. The median GGT/HDL-C ratio was 1.1 [0.7 - 1.5], and 83.9% of patients experienced resolution of MetS. Furthermore, both the middle tertile of GGT/HDL-C (aRR: 1.28; 95% CI: 1.04 - 1.58; p = .019) and the lowest tertile (aRR: 1.27; 95% CI: 1.01 - 1.60; p = .038) showed a significant association with the resolution of MetS.
      Conclusion: Eight out of 10 patients undergoing SG experience resolution of MetS within 6 months after surgery. Patients in the middle and lower tertiles of the GGT/HDL-C were more likely to achieve this outcome. Therefore, the GGT/HDL-C ratio should be considered a valuable and efficient biomarker for preoperative assessment of bariatric surgery candidates.
      Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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    • Contributed Indexing:
      Keywords: HDL (MeSH-NLM); Metabolic syndrome; bariatric surgery; cholesterol; gamma-Glutamyltransferase; lipoproteins; obesity
    • Accession Number:
      0 (Biomarkers)
      0 (Cholesterol, HDL)
      EC 2.3.2.2 (gamma-Glutamyltransferase)
      EC 2.3.2.2 (gamma-glutamyltransferase, human)
    • Publication Date:
      Date Created: 20240503 Date Completed: 20240503 Latest Revision: 20240523
    • Publication Date:
      20240523
    • Accession Number:
      PMC11069333
    • Accession Number:
      10.1177/14791641241252553
    • Accession Number:
      38702054