Short-term, nonsurgical periodontal therapy boosts interleukin-12 levels and reduces oral cancer risk.

Publisher: Royal Academy of Medicine of Ireland Country of Publication: Ireland NLM ID: 7806864 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1863-4362 (Electronic) Linking ISSN: 00211265 NLM ISO Abbreviation: Ir J Med Sci Subsets: MEDLINE

Original Publication: Dublin : Royal Academy of Medicine of Ireland

Interleukin-12*/blood ; Mouth Neoplasms*/therapy ; Chronic Periodontitis*/therapy ; Chronic Periodontitis*/immunology; Humans ; Male ; Middle Aged ; Female ; Adult ; Periodontal Index

Background: Cytokines, including interleukin-12 (IL-12), are proteins that regulate cell survival, proliferation, differentiation, and function. IL-12 is a heterodimeric proinflammatory cytokine. It possesses tumoricidal properties and promotes M1 macrophage polarization and IFN-γ production by T helper (Th1) cells, which in turn stimulates the antitumor cytotoxic cluster of eight positive (CD8+) and natural killer cells, therefore activating an effector immune response against tumor cells.
Materials and Methods: Herein, the IL-2 levels of 60 patients with generalized chronic periodontitis (GCP) were assessed. Plaque index, gingival index, pocket probing depth, bleeding on probing percentage (BOP %), and clinical attachment loss were the clinical indicators reported.
Results: Patients with GCP in the pretreatment group had substantially lower mean IL-12 levels than those in the post-treatment group. Short-term, nonsurgical treatment (NST) considerably improved periodontal indices and increased IL-12 levels, thereby reducing oral cancer risk.
Conclusion: NST is a cost-effective and accessible cancer prevention procedure for general dentists.
(© 2024. The Author(s), under exclusive licence to Royal Academy of Medicine in Ireland.)

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1404-BA Deanship of Scientific Research, University of Ha'il

Keywords: Chronic periodontitis; Interleukin-12; Oral cancer; Short-term nonsurgical treatment

187348-17-0 (Interleukin-12)

Date Created: 20240502 Date Completed: 20240801 Latest Revision: 20240801

20240801

10.1007/s11845-024-03695-5

38698250