Rathke's Cleft Cyst and Craniopharyngioma: A Continuum of the Same Spectrum? Insights from an Interesting Case and Previous Literature.

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  • Additional Information
    • Source:
      Publisher: Medknow Publications Country of Publication: India NLM ID: 0042005 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1998-4022 (Electronic) Linking ISSN: 00283886 NLM ISO Abbreviation: Neurol India Subsets: MEDLINE
    • Publication Information:
      Publication: Mumbai : Medknow Publications
      Original Publication: Bombay : Neurological Society of India
    • Subject Terms:
      Craniopharyngioma*/surgery ; Craniopharyngioma*/pathology ; Craniopharyngioma*/diagnostic imaging ; Craniopharyngioma*/diagnosis ; Central Nervous System Cysts*/surgery ; Central Nervous System Cysts*/pathology ; Central Nervous System Cysts*/diagnostic imaging ; Pituitary Neoplasms*/pathology ; Pituitary Neoplasms*/surgery ; Pituitary Neoplasms*/diagnostic imaging; Humans ; Female ; Adult
    • Abstract:
      Rathke's Cleft Cysts (RCCs) and Craniopharyngiomas (CPs) may represent disease entities on the same etio-pathological spectrum. We report the case of a 36-year-old female presenting with vision loss and menstrual irregularities, imaging shows a predominantly cystic lesion in the sellar region with suprasellar extension. She underwent a microscopic transnasal resection of the lesion. She later presented with recurrent symptoms and increased residual lesion size on imaging, a transcranial excision of the lesion was performed. Histopathology from the initial operative specimen revealed RCC with squamous metaplasia which was BRAF negative, while the specimen from the second surgery revealed BRAF positive papillary stratified squamous architecture suggestive of Papillary CP. This case adds to the evidence that both RCCs and papillary CPs may be the spectrum of the same disease. Further, papillary CPs may be an evolution from the RCCs.
      (Copyright © 2024 Copyright: © 2024 Neurology India, Neurological Society of India.)
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    • Publication Date:
      Date Created: 20240501 Date Completed: 20240501 Latest Revision: 20240702
    • Publication Date:
      20240702
    • Accession Number:
      10.4103/ni.ni_1210_21
    • Accession Number:
      38691485