Quercetin attenuates inflammation in rosacea by directly targeting p65 and ICAM-1.

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  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0631 (Electronic) Linking ISSN: 00243205 NLM ISO Abbreviation: Life Sci Subsets: MEDLINE
    • Publication Information:
      Publication: <2008->: Amsterdam : Elsevier
      Original Publication: Oxford; Elmsford, N. Y. [etc.] Pergamon Press.
    • Subject Terms:
      Quercetin*/pharmacology ; Intercellular Adhesion Molecule-1*/metabolism ; Rosacea*/drug therapy ; Rosacea*/metabolism ; Inflammation*/drug therapy ; Inflammation*/metabolism ; Transcription Factor RelA*/metabolism; Humans ; Animals ; Molecular Docking Simulation ; Mice ; Female ; Male
    • Abstract:
      Aims: Rosacea is an inflammatory skin disease with immune and vascular dysfunction. Although there are multiple treatment strategies for rosacea, the clinical outcomes are unsatisfactory.
      Main Methods: Combining transcriptome data and the Connectivity Map database quercetin was identified as a novel candidate for rosacea. Next, the therapeutic efficacy of quercetin was substantiated through proteomic analyses, in vivo experiments, and in vitro assays. Additionally, the utilization of DARTS, molecular docking and experimental verification revealed the therapeutic mechanisms of quercetin.
      Key Findings: Treatment with quercetin resulted in the following effects: (i) it effectively ameliorated rosacea-like features by reducing immune infiltration and angiogenesis; (ii) it suppressed the expression of inflammatory mediators in HaCaT cells and HDMECs; (iii) it interacted with p65 and ICAM-1 directly, and this interaction resulted in the repression of NF-κB signal and ICAM-1 expression in rosacea.
      Significance: We show for the first time that quercetin interacted with p65 and ICAM-1 directly to alleviated inflammatory and vascular dysfunction, suggesting quercetin is a novel, promising therapeutic candidate for rosacea.
      Competing Interests: Declaration of competing interest Author Qian Wang is employed by Hunan Binsis Biotechnology Co. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The authors declare that they have no conflict of interest.
      (Copyright © 2024 Elsevier Inc. All rights reserved.)
    • Contributed Indexing:
      Keywords: Angiogenesis; Immune infiltration; Quercetin; rosacea
    • Accession Number:
      9IKM0I5T1E (Quercetin)
      126547-89-5 (Intercellular Adhesion Molecule-1)
      0 (Transcription Factor RelA)
      0 (ICAM1 protein, human)
      0 (RELA protein, human)
    • Publication Date:
      Date Created: 20240430 Date Completed: 20240510 Latest Revision: 20240531
    • Publication Date:
      20240531
    • Accession Number:
      10.1016/j.lfs.2024.122675
    • Accession Number:
      38688383