Targeting cardiomyocyte cell cycle regulation in heart failure.

Publisher: Steinkopff Country of Publication: Germany NLM ID: 0360342 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1435-1803 (Electronic) Linking ISSN: 03008428 NLM ISO Abbreviation: Basic Res Cardiol Subsets: MEDLINE

Original Publication: Darmstadt, Steinkopff.

Heart Failure*/physiopathology ; Heart Failure*/metabolism ; Heart Failure*/pathology ; Myocytes, Cardiac*/metabolism ; Myocytes, Cardiac*/pathology ; Cell Cycle* ; Cell Proliferation*; Humans ; Animals ; Regeneration

Heart failure continues to be a significant global health concern, causing substantial morbidity and mortality. The limited ability of the adult heart to regenerate has posed challenges in finding effective treatments for cardiac pathologies. While various medications and surgical interventions have been used to improve cardiac function, they are not able to address the extensive loss of functioning cardiomyocytes that occurs during cardiac injury. As a result, there is growing interest in understanding how the cell cycle is regulated and exploring the potential for stimulating cardiomyocyte proliferation as a means of promoting heart regeneration. This review aims to provide an overview of current knowledge on cell cycle regulation and mechanisms underlying cardiomyocyte proliferation in cases of heart failure, while also highlighting established and novel therapeutic strategies targeting this area for treatment purposes.
(© 2024. The Author(s).)

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822455 European Innovation Council; SFB/TR267 Deutsche Forschungsgemeinschaft

Keywords: Cardiomyocyte proliferation; Cell cycle; Heart failure

Date Created: 20240429 Date Completed: 20240531 Latest Revision: 20241010

20241011

PMC11142990

10.1007/s00395-024-01049-x

38683371