Reservoir displacement by an invasive rodent reduces Lassa virus zoonotic spillover risk.

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  • Additional Information
    • Source:
      Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
    • Publication Information:
      Original Publication: [London] : Nature Pub. Group
    • Subject Terms:
      Lassa virus*/pathogenicity ; Lassa virus*/physiology ; Lassa Fever*/transmission ; Lassa Fever*/epidemiology ; Lassa Fever*/virology ; Lassa Fever*/veterinary ; Introduced Species* ; Disease Reservoirs*/virology ; Murinae*/virology ; Zoonoses*/virology ; Zoonoses*/transmission ; Zoonoses*/epidemiology; Animals ; Humans ; Rats ; Sierra Leone/epidemiology ; Guinea/epidemiology ; Ecosystem ; Rodent Diseases/virology ; Rodent Diseases/epidemiology ; Rodent Diseases/transmission
    • Abstract:
      The black rat (Rattus rattus) is a globally invasive species that has been widely introduced across Africa. Within its invasive range in West Africa, R. rattus may compete with the native rodent Mastomys natalensis, the primary reservoir host of Lassa virus, a zoonotic pathogen that kills thousands annually. Here, we use rodent trapping data from Sierra Leone and Guinea to show that R. rattus presence reduces M. natalensis density within the human dwellings where Lassa virus exposure is most likely to occur. Further, we integrate infection data from M. natalensis to demonstrate that Lassa virus zoonotic spillover risk is lower at sites with R. rattus. While non-native species can have numerous negative effects on ecosystems, our results suggest that R. rattus invasion has the indirect benefit of decreasing zoonotic spillover of an endemic pathogen, with important implications for invasive species control across West Africa.
      (© 2024. The Author(s).)
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    • Grant Information:
      R01 GM122079 United States GM NIGMS NIH HHS; R01GM122079 U.S. Department of Health & Human Services | National Institutes of Health (NIH); DEB 2028162 National Science Foundation (NSF); D18AC00028 United States Department of Defense | Defense Advanced Research Projects Agency (DARPA)
    • Publication Date:
      Date Created: 20240427 Date Completed: 20240427 Latest Revision: 20240616
    • Publication Date:
      20240616
    • Accession Number:
      PMC11055883
    • Accession Number:
      10.1038/s41467-024-47991-1
    • Accession Number:
      38678025