Structure, Functions, and Implications of Selected Lipocalins in Human Disease.

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  • Additional Information
    • Source:
      Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
    • Publication Information:
      Original Publication: Basel, Switzerland : MDPI, [2000-
    • Subject Terms:
      Lipocalins*/metabolism ; Lipocalins*/chemistry ; Lipocalins*/genetics ; Intramolecular Oxidoreductases*; Humans ; Neoplasms/metabolism ; Structure-Activity Relationship ; Animals
    • Abstract:
      The lipocalin proteins are a large family of small extracellular proteins that demonstrate significant heterogeneity in sequence similarity and have highly conserved crystal structures. They have a variety of functions, including acting as carrier proteins, transporting retinol, participating in olfaction, and synthesizing prostaglandins. Importantly, they also play a critical role in human diseases, including cancer. Additionally, they are involved in regulating cellular homeostasis and immune response and dispensing various compounds. This comprehensive review provides information on the lipocalin family, including their structure, functions, and implications in various diseases. It focuses on selective important human lipocalin proteins, such as lipocalin 2 (LCN2), retinol binding protein 4 (RBP4), prostaglandin D2 synthase (PTGDS), and α 1 -microglobulin (A1M).
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    • Contributed Indexing:
      Keywords: A1M; LCN2; PTGDS; RBP4; cancer; carrier proteins; human disease; lipocalins; structure; transport proteins
    • Accession Number:
      0 (Lipocalins)
      EC 5.3.99.2 (prostaglandin R2 D-isomerase)
      EC 5.3.- (Intramolecular Oxidoreductases)
    • Publication Date:
      Date Created: 20240427 Date Completed: 20240427 Latest Revision: 20240513
    • Publication Date:
      20250114
    • Accession Number:
      PMC11050150
    • Accession Number:
      10.3390/ijms25084290
    • Accession Number:
      38673873