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Sex-specific differences in myocardial glucose metabolic rate in non-diabetic, pre-diabetic and type 2 diabetic subjects.
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- Author(s): Succurro E;Succurro E;Succurro E; Vizza P; Vizza P; Cicone F; Cicone F; Cassano V; Cassano V; Massimino M; Massimino M; Giofrè F; Giofrè F; Fiorentino TV; Fiorentino TV; Perticone M; Perticone M; Sciacqua A; Sciacqua A; Sciacqua A; Guzzi PH; Guzzi PH; Veltri P; Veltri P; Andreozzi F; Andreozzi F; Andreozzi F; Cascini GL; Cascini GL; Sesti G; Sesti G
- Source:
Cardiovascular diabetology [Cardiovasc Diabetol] 2024 Apr 26; Vol. 23 (1), pp. 144. Date of Electronic Publication: 2024 Apr 26.- Publication Type:
Journal Article; Research Support, Non-U.S. Gov't; Comparative Study- Language:
English - Source:
- Additional Information
- Source: Publisher: BioMed Central Country of Publication: England NLM ID: 101147637 Publication Model: Electronic Cited Medium: Internet ISSN: 1475-2840 (Electronic) Linking ISSN: 14752840 NLM ISO Abbreviation: Cardiovasc Diabetol Subsets: MEDLINE
- Publication Information: Original Publication: London : BioMed Central, [2002-
- Subject Terms: Diabetes Mellitus, Type 2*/diagnosis ; Diabetes Mellitus, Type 2*/metabolism ; Diabetes Mellitus, Type 2*/epidemiology ; Prediabetic State*/metabolism ; Prediabetic State*/diagnosis ; Prediabetic State*/epidemiology ; Insulin Resistance* ; Myocardium*/metabolism ; Blood Glucose*/metabolism ; Glucose Clamp Technique*; Humans ; Male ; Female ; Middle Aged ; Sex Factors ; Adult ; Aged ; Biomarkers/blood ; Fluorodeoxyglucose F18 ; Positron-Emission Tomography ; Radiopharmaceuticals ; Insulin/blood ; Case-Control Studies ; Energy Metabolism
- Abstract: Background: Evidence has shown that women with type 2 diabetes (T2DM) have a higher excess risk for cardiovascular disease (CVD) than men with T2DM. Subjects with either T2DM or prediabetes exhibit myocardial insulin resistance, but it is still unsettled whether sex-related differences in myocardial insulin resistance occur in diabetic and prediabetic subjects.
Methods: We aimed to evaluate sex-related differences in myocardial glucose metabolic rate (MRGlu), assessed using dynamic PET with 18 F-FDG combined with euglycemic-hyperinsulinemic clamp, in subjects with normal glucose tolerance (NGT; n = 20), prediabetes (n = 11), and T2DM (n = 26).
Results: Women with prediabetes or T2DM exhibited greater relative differences in myocardial MRGlu than men with prediabetes or T2DM when compared with their NGT counterparts. As compared with women with NGT, those with prediabetes exhibited an age-adjusted 35% lower myocardial MRGlu value (P = 0.04) and women with T2DM a 74% lower value (P = 0.006), respectively. Conversely, as compared with men with NGT, men with T2DM exhibited a 40% lower myocardial MRGlu value (P = 0.004), while no significant difference was observed between men with NGT and prediabetes. The statistical test for interaction between sex and glucose tolerance on myocardial MRGlu (P < 0.0001) was significant suggesting a sex-specific association.
Conclusions: Our data suggest that deterioration of glucose homeostasis in women is associated with a greater impairment in myocardial glucose metabolism as compared with men. The sex-specific myocardial insulin resistance could be an important factor responsible for the greater effect of T2DM on the excess risk of cardiovascular disease in women than in men.
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Diabetologia. 2014 Aug;57(8):1542-51. (PMID: 24859435) - Contributed Indexing: Keywords: Cardiac 18F-FDG PET; Cardiovascular disease; Myocardial glucose metabolism; Prediabetes; Sex-differences; Type 2 diabetes
- Accession Number: 0 (Blood Glucose)
0 (Biomarkers)
0Z5B2CJX4D (Fluorodeoxyglucose F18)
0 (Radiopharmaceuticals)
0 (Insulin) - Publication Date: Date Created: 20240426 Date Completed: 20240427 Latest Revision: 20240429
- Publication Date: 20240429
- Accession Number: PMC11055246
- Accession Number: 10.1186/s12933-024-02246-7
- Accession Number: 38671460
- Source:
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