Urinary Metabolites of Polycyclic Aromatic Hydrocarbons of Rural Population in Northwestern China: Oxidative Stress and Health Risk Assessment.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Additional Information
    • Source:
      Publisher: American Chemical Society Country of Publication: United States NLM ID: 0213155 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5851 (Electronic) Linking ISSN: 0013936X NLM ISO Abbreviation: Environ Sci Technol Subsets: MEDLINE
    • Publication Information:
      Publication: Washington DC : American Chemical Society
      Original Publication: Easton, Pa. : American Chemical Society, c1967-
    • Subject Terms:
      Polycyclic Aromatic Hydrocarbons*/urine ; Oxidative Stress* ; Rural Population* ; Biomarkers*/urine; Humans ; China ; Risk Assessment ; Male ; Female ; Environmental Exposure ; Middle Aged ; Adult
    • Abstract:
      Polycyclic aromatic hydrocarbon (PAH) exposure is suspected to be linked to oxidative damage. Herein, ten PAH human exposure biomarkers [hydroxylated PAH metabolites (OH-PAHs)] and five oxidative stress biomarkers (OSBs) were detected in urine samples collected from participants living in a rural area ( n = 181) in Northwestern China. The median molar concentration of ΣOH-PAHs in urine was 47.0 pmol mL -1 . The 2-hydroxynaphthalene (2-OHNap; median: 2.21 ng mL -1 ) was the dominant OH-PAH. The risk assessment of PAH exposure found that hazard index (HI) values were <1, indicating that the PAH exposure of rural people in Jingyuan would not generate significant cumulative risks. Smokers (median: 0.033) obtained higher HI values than nonsmokers (median: 0.015, p < 0.01), suggesting that smokers face a higher health risk from PAH exposure than nonsmokers. Pearson correlation and multivariate linear regression analysis revealed that ΣOH-PAH concentrations were significant factors in increasing the oxidative damage to deoxyribonucleic acid (DNA) (8-hydroxy-2'-deoxyguanosine, 8-OHdG), ribonucleic acid (RNA) (8-oxo-7,8-dihydroguanine, 8-oxoGua), and protein ( o , o '-dityrosine, diY) ( p < 0.05). Among all PAH metabolites, only 1-hydroxypyrene (1-OHPyr) could positively affect the expression of all five OSBs ( p < 0.05), suggesting that urinary 1-OHPyr might be a reliable biomarker for PAH exposure and a useful indicator for assessing the impacts of PAH exposure on oxidative stress. This study is focused on the relation between PAH exposure and oxidative damage and lays a foundation for the study of the health effect mechanism of PAHs.
    • Contributed Indexing:
      Keywords: exposure; human urine; oxidative stress; polycyclic aromatic hydrocarbons; risk assessment
    • Accession Number:
      0 (Polycyclic Aromatic Hydrocarbons)
      0 (Biomarkers)
    • Publication Date:
      Date Created: 20240426 Date Completed: 20240507 Latest Revision: 20240507
    • Publication Date:
      20240507
    • Accession Number:
      10.1021/acs.est.4c00122
    • Accession Number:
      38669205