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Urinary Metabolites of Polycyclic Aromatic Hydrocarbons of Rural Population in Northwestern China: Oxidative Stress and Health Risk Assessment.
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- Author(s): Hua L;Hua L;Hua L; Gao Y; Gao Y; Guo S; Guo S; Zhu H; Zhu H; Yao Y; Yao Y; Wang B; Wang B; Fang J; Fang J; Sun H; Sun H; Xu F; Xu F; Zhao H; Zhao H
- Source:
Environmental science & technology [Environ Sci Technol] 2024 May 07; Vol. 58 (18), pp. 7758-7769. Date of Electronic Publication: 2024 Apr 26.- Publication Type:
Journal Article; Research Support, Non-U.S. Gov't- Language:
English - Source:
- Additional Information
- Source: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0213155 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5851 (Electronic) Linking ISSN: 0013936X NLM ISO Abbreviation: Environ Sci Technol Subsets: MEDLINE
- Publication Information: Publication: Washington DC : American Chemical Society
Original Publication: Easton, Pa. : American Chemical Society, c1967- - Subject Terms:
- Abstract: Polycyclic aromatic hydrocarbon (PAH) exposure is suspected to be linked to oxidative damage. Herein, ten PAH human exposure biomarkers [hydroxylated PAH metabolites (OH-PAHs)] and five oxidative stress biomarkers (OSBs) were detected in urine samples collected from participants living in a rural area ( n = 181) in Northwestern China. The median molar concentration of ΣOH-PAHs in urine was 47.0 pmol mL -1 . The 2-hydroxynaphthalene (2-OHNap; median: 2.21 ng mL -1 ) was the dominant OH-PAH. The risk assessment of PAH exposure found that hazard index (HI) values were <1, indicating that the PAH exposure of rural people in Jingyuan would not generate significant cumulative risks. Smokers (median: 0.033) obtained higher HI values than nonsmokers (median: 0.015, p < 0.01), suggesting that smokers face a higher health risk from PAH exposure than nonsmokers. Pearson correlation and multivariate linear regression analysis revealed that ΣOH-PAH concentrations were significant factors in increasing the oxidative damage to deoxyribonucleic acid (DNA) (8-hydroxy-2'-deoxyguanosine, 8-OHdG), ribonucleic acid (RNA) (8-oxo-7,8-dihydroguanine, 8-oxoGua), and protein ( o , o '-dityrosine, diY) ( p < 0.05). Among all PAH metabolites, only 1-hydroxypyrene (1-OHPyr) could positively affect the expression of all five OSBs ( p < 0.05), suggesting that urinary 1-OHPyr might be a reliable biomarker for PAH exposure and a useful indicator for assessing the impacts of PAH exposure on oxidative stress. This study is focused on the relation between PAH exposure and oxidative damage and lays a foundation for the study of the health effect mechanism of PAHs.
- Contributed Indexing: Keywords: exposure; human urine; oxidative stress; polycyclic aromatic hydrocarbons; risk assessment
- Accession Number: 0 (Polycyclic Aromatic Hydrocarbons)
0 (Biomarkers) - Publication Date: Date Created: 20240426 Date Completed: 20240507 Latest Revision: 20240507
- Publication Date: 20240507
- Accession Number: 10.1021/acs.est.4c00122
- Accession Number: 38669205
- Source:
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