Plasmalogens Alter the Aggregation Rate of Transthyretin and Lower Toxicity of Transthyretin Fibrils.

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  • Additional Information
    • Source:
      Publisher: American Chemical Society Country of Publication: United States NLM ID: 101526034 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1948-7185 (Electronic) Linking ISSN: 19487185 NLM ISO Abbreviation: J Phys Chem Lett Subsets: MEDLINE
    • Publication Information:
      Original Publication: Washington, D.C. : American Chemical Society
    • Subject Terms:
      Prealbumin*/chemistry ; Prealbumin*/metabolism ; Plasmalogens*/metabolism ; Plasmalogens*/chemistry; Humans ; Amyloid/chemistry ; Amyloid/metabolism ; Protein Aggregates/drug effects ; Fatty Acids/chemistry ; Fatty Acids/metabolism
    • Abstract:
      Heart tissue can experience a progressive accumulation of transthyretin (TTR), a small four subunit protein that transports holoretinol binding protein and thyroxine. This severe pathology is known as transthyretin amyloid cardiomyopathy. Numerous experimental studies indicated that the aggregation rate and toxicity of TTR fibrils could be altered by the presence of lipids; however, the role of plasmalogens in this process remains unknown. In this study, we investigate the effect of choline plasmalogens (CPs) with different lengths and saturations of fatty acids (FAs) on TTR aggregation. We found that CPs with saturated and unsaturated FAs strongly suppressed TTR aggregation. We also found that CPs with saturated FAs did not change the morphology of TTR fibrils; however, much thicker fibrillar species were formed in the presence of CPs with unsaturated FAs. Finally, we found that CPs with C16:0, C18:0, and C18:1 FAs substantially lowered the cytotoxicity of TTR fibrils that were formed in their presence.
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    • Grant Information:
      R35 GM142869 United States GM NIGMS NIH HHS
    • Accession Number:
      0 (Prealbumin)
      0 (Plasmalogens)
      0 (Amyloid)
      0 (Protein Aggregates)
      0 (Fatty Acids)
      0 (TTR protein, human)
    • Publication Date:
      Date Created: 20240425 Date Completed: 20240502 Latest Revision: 20240508
    • Publication Date:
      20240508
    • Accession Number:
      PMC11071038
    • Accession Number:
      10.1021/acs.jpclett.4c00868
    • Accession Number:
      38661515