Effect of cholecalciferol supplementation on hand grip strength, walking speed, and expression of vitamin D receptor, interleukin-6, and insulin-like growth factor-1 in monocyte in pre-frail older adults: A randomized double-blind placebo-controlled trial.

Publisher: Japan Geriatrics Society Country of Publication: Japan NLM ID: 101135738 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1447-0594 (Electronic) Linking ISSN: 14470594 NLM ISO Abbreviation: Geriatr Gerontol Int Subsets: MEDLINE

Original Publication: [Tokyo, Japan] : Carlton, Vic., Australia : Japan Geriatrics Society ; Blackwell Science, c2001-

Hand Strength*/physiology ; Interleukin-6*/blood ; Cholecalciferol*/administration & dosage ; Monocytes*/metabolism ; Monocytes*/drug effects ; Receptors, Calcitriol*/metabolism ; Dietary Supplements* ; Insulin-Like Growth Factor I*/metabolism ; Walking Speed*; Humans ; Male ; Double-Blind Method ; Aged ; Female ; Aged, 80 and over ; Frail Elderly ; Vitamin D/blood ; Vitamins/administration & dosage ; Insulin-Like Peptides

Aim: To investigate the effect of cholecalciferol supplementation on hand grip strength, walking speed, and expression of vitamin D receptor (VDR), interleukine-6 (IL-6) and insulin-like growth factor-1 (IGF-1) in monocyte in pre-frail older adults.
Methods: We conducted a randomized double-blinded placebo-controlled clinical trial for 12 weeks, involving 120 pre-frail older adults who were randomized to the cholecalciferol group (cholecalciferol 4000 IU/day) or the placebo group. All subjects were given calcium lactate 500 mg/day. Hand grip strength and walking speed, as primary outcomes, were analyzed using intention-to-treat analysis. The expression of VDR, IGF-1 and IL-6 in monocytes, as secondary outcomes, were analyzed using per-protocol analysis.
Results: After a 12-week intervention, there was a significant increase in serum 25(OH)D levels in both groups, with the increase being higher in the cholecalciferol group than in the placebo group (49.05 vs. 24.01 ng/mL; P < 0.001). No statistically significant differences were observed in hand grip strength (P = 0.228) and walking speed (P = 0.734) between the groups. There were no differences in the expression of VDR (P = 0.513), IL-6 (P = 0.509), and IGF-1 (P = 0.503) monocytes between the groups.
Conclusions: Cholecalciferol supplementation for 12 weeks increased serum 25(OH)D levels among pre-frail older adults. However, it did not improve hand grip strength and walking speed, and nor did it change the expression of VDR, IL-6, and IGF-1 in monocytes. Geriatr Gerontol Int 2024; 24: 554-562.
(© 2024 Japan Geriatrics Society.)

Erratum in: Geriatr Gerontol Int. 2024 Aug 21. doi: 10.1111/ggi.14960. (PMID: 39166366)

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NKB-1255/UN2.RST/HKP.05.00/2022 Direktorat Riset and Pengembangan, Universitas Indonesia Hibah Publikasi Terindeks International (PUTI) 2022

Keywords: cholecalciferol; hand grip strength; monocytes; pre‐frail older adult; walking speed

0 (Interleukin-6)
1C6V77QF41 (Cholecalciferol)
0 (Receptors, Calcitriol)
67763-96-6 (Insulin-Like Growth Factor I)
1406-16-2 (Vitamin D)
0 (IL6 protein, human)
0 (Vitamins)
0 (Insulin-Like Peptides)

Date Created: 20240422 Date Completed: 20240602 Latest Revision: 20240821

20240821

10.1111/ggi.14881

38644647