How ceramides affect the development of colon cancer: from normal colon to carcinoma.

Publisher: Springer Country of Publication: Germany NLM ID: 0154720 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-2013 (Electronic) Linking ISSN: 00316768 NLM ISO Abbreviation: Pflugers Arch Subsets: MEDLINE

Original Publication: Berlin, New York, Springer.

Ceramides*/metabolism ; Colonic Neoplasms*/metabolism; Humans ; Animals ; Colon/metabolism ; Colon/pathology ; Signal Transduction

The integrity of the colon and the development of colon cancer depend on the sphingolipid balance in colon epithelial cells. In this review, we summarize the current knowledge on how ceramides and their complex derivatives influence normal colon development and colon cancer development. Ceramides, glucosylceramides and sphingomyelin are essential membrane components and, due to their biophysical properties, can influence the activation of membrane proteins, affecting protein-protein interactions and downstream signalling pathways. Here, we review the cellular mechanisms known to be affected by ceramides and their effects on colon development. We also describe which ceramides are deregulated during colorectal carcinogenesis, the molecular mechanisms involved in ceramide deregulation and how this affects carcinogenesis. Finally, we review new methods that are now state of the art for studying lipid-protein interactions in the physiological environment.
Competing Interests: Declarations. Ethical approval: Not applicable. Competing interests: All other authors stated no potential conflicts neither financial, professional, nor personal to be relevant to the manuscript. All authors agree to the content of the manuscript.
(© 2024. The Author(s).)

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SFB1039, B05 Deutsche Forschungsgemeinschaft

Keywords: Ceramide synthase; Colon cancer; Crypt; Hypoxia; Sphingolipid; Stem cell

0 (Ceramides)

Date Created: 20240418 Date Completed: 20241121 Latest Revision: 20241210

20241210

PMC11582153

10.1007/s00424-024-02960-x

38635059